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UI - Makalah dan Kertas Kerja :: Kembali

Judul In Silico Study of Flavonoid Interacting with Dopamine D2 Receptor (Poster Presentation) - International Conference on Medicinal Chemistry and Timmerman Award 2013 Universitas Indonesia, 28 -29th October 2013
Nomor Panggil MK-Pdf
Pengarang
Pengarang/kontributor lain
Subjek
Penerbitan 2013
Kata Kunci farmasi · prolactin antagonist · Dopamine ·
 Info Lainnya
Sumber Pengatalogan LibUI eng rda
Tipe Konten text (rdacontent)
Tipe Media computer (rdamedia)
Tipe Carrier online resource (rdacarrier)
Deskripsi Fisik 5 pages
Lembaga Pemilik Universitas Indonesia
Lokasi Perpustakaan UI, Lantai 3
  • Ketersediaan
  • File Digital: 1
  • Ulasan
  • Sampul
  • Abstrak
  • Tampilan MARC
Nomor Panggil No. Barkod Ketersediaan
MK-Pdf 10-17-968803210 TERSEDIA
Ulasan:
Tidak ada ulasan pada koleksi ini: 20461546
As a prolactin antagonist, dopamine binds to its receptor D2 and suppresses the secretion of prolactin
from the pituitary gland. Required ligand that can interact with receptor so that dopamine can no
longer bound to its receptor. Ligands empirically derived from plants and have been proven to
increase human lactation. In silico study using molecular docking technique to identify ligand
interaction with dopamine D2 receptor (PDB: 1I15). The best posing and binding energy (ΔG) were
analyzed and ranked to get potential dopamine D2 receptor inhibitor. Binding energy of apigenin,
luteolin, kaempferol, quercetin, and myricetin with PDB: 1I15 gives value respectively -5.90, -5.67, -
5.64, -5.28, -4.36 kcal/mol. Interaction occurred between the ligand and amino acid residue ASN 192,
PRO 204, SER 209 formed hydrogen bonding and hydrophobic interaction with HIS 189.
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040LibUI eng rda
041eng
049[10-17-968803210]
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090MK-Pdf
100Indri Indrawan, author
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245|a In Silico Study of Flavonoid Interacting with Dopamine D2 Receptor (Poster Presentation) - International Conference on Medicinal Chemistry and Timmerman Award 2013 Universitas Indonesia, 28 -29th October 2013 |c
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260|a |b |c 2013
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3005 pages
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336text (rdacontent)
337computer (rdamedia)
338online resource (rdacarrier)
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502Poster Seminar
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520As a prolactin antagonist, dopamine binds to its receptor D2 and suppresses the secretion of prolactin from the pituitary gland. Required ligand that can interact with receptor so that dopamine can no longer bound to its receptor. Ligands empirically derived from plants and have been proven to increase human lactation. In silico study using molecular docking technique to identify ligand interaction with dopamine D2 receptor (PDB: 1I15). The best posing and binding energy (ΔG) were analyzed and ranked to get potential dopamine D2 receptor inhibitor. Binding energy of apigenin, luteolin, kaempferol, quercetin, and myricetin with PDB: 1I15 gives value respectively -5.90, -5.67, - 5.64, -5.28, -4.36 kcal/mol. Interaction occurred between the ligand and amino acid residue ASN 192, PRO 204, SER 209 formed hydrogen bonding and hydrophobic interaction with HIS 189.
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546Bahasa Inggris
590[]
650Flavonoids -- pharmacology; Dopamine
653farmasi; prolactin antagonist; Dopamine
700Nuri Andarwulan, author; Nancy Dewi Yuliana, author; Arry Yanuar, author
710Universitas Indonesia. Fakultas Farmasi
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850Universitas Indonesia
852Perpustakaan UI, Lantai 3
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