| 001 Hak Akses (open/membership) | membership |
| 700 Entri Tambahan Nama Orang | Mohamad Sadikin, promotor; Claire Rampon, co-promotor; Marie-Christine Miquel, co-promotor; Nurhadi Ibrahim, co-promotor; Marie christine Miquel, examiner; Purba, Jan S., examiner; Marisol Corral Debrinski, examiner; Sri Widia Jusman, examiner; Wawaimuli Arozal, examiner |
| 336 Content Type | text (rdacontent) |
| 264b Nama Penerbit | Fakultas Kedokteran Universitas Indonesia |
| 710 Entri Tambahan Badan Korporasi | |
| 049 No. Barkod | 07-18-896148469 |
| 504 Catatan Bibliografi | pages 121-140 |
| 852 Lokasi | Perpustakaan UI, Lantai 3 |
| 338 Carrier Type | online resource (rdacarrier) |
| 590 Cat. Sumber Pengadaan Koleksi | Unggah UI-ANA-11 |
| 903 Stock Opname | |
| 534 Catatan Versi Asli | |
| Tahun Buka Akses | 2020 |
| 053 No. Induk | 07-18-896148469 |
| 653 Kata Kunci | neurogenesis; mitochondria; hippocampus; pattern separation; neurod1; opa1 |
| 040 Sumber Pengatalogan | LibUI ind rda |
| 245 Judul Utama | Neurogenesis dewasa dan mitokondria berperan pada plastisitas hipokampus pada model mencit penyakit neurodegeneratif = Adult neurogenesis and mitochondria play a role in hippocampal plasticity in mouse models of neurodegenerative disesases |
| 264c Tahun Terbit | 2017 |
| 650 Subyek Topik | Neurodegenerative diseases; Neurodegenerative diseases -- Prevention and control |
| 850 Lembaga Pemilik | Universitas Indonesia |
| 520 Ringkasan/Abstrak/Intisari | Certaines rgions du cerveau adulte, comme l'hippocampe, produisent des nouveaux neurones qui participent certaines capacits d'apprentissage et de m moire. Dans les maladies neurod g n ratives comme la maladie d'Alzheimer MA , ils sont alt r s. Dans des souris mod les de la MA, nous avons montr que ces nouveaux neurones souffraient de plus d'une r duction de leur contenu mitochondrial. Les mitochondries, 'centrales lectriques' des cellules, sont cruciales pour la transmission synaptique. Nous montrons que deux souris mod les diff rents, de MA et de dysfonctionnement mitochondrial, pr sentent une alt ration pr coce des performances de m moire li es ces nouveaux neurones, qui ont une capacit synaptique r duite et moins de mitochondries. De plus, la manipulation g n tique des prog niteurs hippocampiques, chez le premier, r tablit les mitochondries et les synapses. Chez le second, l rsquo;exercice physique augmente les mitochondries et restaure les capacit s mn siques perdues.
......
Some regions of the adult brain, such as the hippocampus, produce new neurons that participate in certain learning and memory capacities. In neurodegenerative diseases, such as Alzheimer's AD , this adult neurogenesis is altered. In a mouse model of AD, we showed that these new neurons have a reduced mitochondrial content and less synaptic capacities. Mitochondria, 'power plants' of cells, are particularly important in neurons and for synaptic transmission. We show that two different mouse models, of AD or of mitochondrial dysfunction, exhibit early impairment of memory performance related to these new neurons, which have less synaptic capacity and fewer mitochondria. In addition, we demonstrate that genetic manipulation of hippocampal progenitors in the former restores mitochondria and synapses. In the second, physical exercise increases mitochondria and restores lost memory abilities. Mitochondria are thus central in cognitive processes related to adult hippocampal neurogenesis. |
| 904b Pemeriksa Lembar Kerja | |
| 090 No. Panggil Setempat | D-Pdf |
| d-Entri Utama Nama Orang | |
| 500 Catatan Umum | Akan ditulis dalam bahasa Inggris untuk dipersiapkan terbit pada Jurnal Internasional yaitu.... - Akan ditulis dalam bahasa Inggris untuk dipersiapkan terbit pada Jurnal Internasional yaitu Neurobiology of Disease yang diprediksi akan dipublikasikan pada bulan Dec tahun 2018 |
| d-Entri Tambahan Nama Orang | |
| 337 Media Type | computer (rdamedia) |
| 526 Catatan Informasi Program Studi | Ilmu Biomedik |
| 100 Entri Utama Nama Orang | Trinovita Andraini, author |
| 264a Kota Terbit | Jakarta |
| 300 Deskripsi Fisik | xxi, 204 pages : illustration ; 28 cm + appendix |
| 904a Pengisi Lembar Kerja | Sutiman |
| Akses Naskah Ringkas | |
| 856 Akses dan Lokasi Elektronik | lib.ui.ac.id/unggah/?q=system/files/node/2017/1/dr.trinovita/trinovita_andraini-disertasi-fakultas_kedokteran-full_text-2017.pdf |
| 502 Catatan Jenis Karya | Disertasi |
| 041 Kode Bahasa | ind |