Tujuan: Mengetahui pengaruh suplementasi 500 mg vitamin C, 6 mg beta-karoten dan 400 IU alfa-tokoferol sehari selama. 2 minggu terhadap fimgsi makula perokok sedang.Desain: Uji klinik eksperimental secara acak dan tersamar gandaMetode: Empat belas perokok sedang mendapatkan suplementasi antioksidan (kelompok perlakuan) 500 mg vitamin C, 6 mg beta-karoten dan 400 IU alfa-tokoferol sehari selama 2 minggu. Empat belas perokok sedang mendapatkan plasebo (kelompok kontrol). Pemeriksaan fovea! threshold, photopic electrorelinography (ERG) dan kadar antioksidan total serum dilakukan pre- dan post-suplementasi.Hasil: Foveal threshold pads kelompok perlakuan dan kelompok kontrol bertuut turut adalah 35,0 ± 3,1 dB dan 31,1 ± 3,0 dB. Amplitudo photopic ERG pada kelompok perlakuan dan kelompok kontrol berturut turut adalah 124,3 ± 34,5 pV dan 72,1 ± 19,9 V. Waktu implistt photopic ERG pads kelompok perlakuan dan kelompok kontrol berturut-turut adalah 33,8 ± 1,4 msec dan 36,6 ± 1,8 msec. Kadar antioksidan total serum pada kelompok perlakuan dan kelompok kontrol berturut turut adalah I,48 ± 0,09 mg/dL dan 1,39 ± 0,11 mg/dL. Terdapat perbedaan bermakna (p<0,05) antara kedua kelompok penelitian.Kesimpulan: Suplementasi 500 mg vitamin C, 6 mg beta-karoten dan 400 IU alfa-tokoferol sehari selama 2 minggu dapat meningkatkan fungsi makula perokok sedang, berupa peningkatan foveal threshold peningkatan amplitudo photopic ERG dan pemendekan waktu implisitphotopic ERG.

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Objective: To evaluate the effects of 2 weeks' supplementation of 500 mg vitamin C, 6 mg beta-carotene and 400 IU alpha-tocopherol daily on macular functions of moderate smokers.

Design: Randomized, double-blind experimental clinical trial

Methods: Fourteen moderate smokers assigned with antioxidants (subject group) 500 mg vitamin C, 6 mg beta-carotene and 400 IU alpha-tocopherol daily for 2 weeks. Fourteen moderate smokers assigned with placebo (control group). Pre- and post-supplementation examination of foveal threshold, photopic electroretinography (ERG) and serum total antioxidant level was done.

Results: Post-supplementation, foveal thresholds in subject group and control group were 35.0 + 3.1 dB and 31.1 + 3.0 dB respectively. Amplitudes of photopic ERG in subject group and control group were 124.3 + 34.5 p.V and 72.1 ± 19.9 RV. Implicit times of photopic ERG in subject group and control group were 33.8 ± 1.4 cosec and 36.6 + 1.8 cosec respectively. Serum total antioxidant levels in subject group and control group were 1.48 ± 0.09 mgldL and 1.39 + 0.11 mg/dL respectively. There were significant differences (p<0,05) between two groups.

Conclusion: Two weeks' supplementation of 500 mg vitamin C, 6 mg beta-carotene and 400 IU alpha-tocopherol daily significantly increases macular function of moderate smokers.