Entry barrier is decrease progressively in era globalization. Because of that quality of product and sen/ice must been takencare. Total of Quality Management ( TQM) represent management quality of service which cannot be disregarded, considering society claim govemment organization have to become servant, government organization must became steward to serve entrepreuner and society because our entrepreneur and society want get service from government organization quick, accurate and trusted.National Agency of Drug and Food Control (NADFC) since year 2001 haveintended to implement good service program which in line with TQM, but in its applying still face some constraint so that good service able to satisfied customer/ client not yet fully can be executed.To know how far applying of TQM and constraints faced and why service not doing better its need research scientifically.Leadership, Komitmen, Process and Product in Organization is to represent very important organizational pillar in applying of TQM (ISO 9000). which must evaluate continually that because of staff and head in band quality control of narcotic and psikotropic are beiing sample population I tne research each officer work with profesional speed, credible as according to organizational culture of NADFC so satisfaction of customer/client can be reach.Sampel determined with technique of Non Probability Sampling Purposive That mean Sampel have been determined owning certain specification and strata with use kuesioner.That kuesioner are full with quesition and andswer with use likert scale disseminating containing kuesioner of question with answer by usinglikert scale, result of kuesioner analysed correlationly doubled regresi and constructively SPSS program 11.5Result of research to Leadership factors, Komitmen, Process and Product in Organization is to represent Organizational Pillar according to in TQM theory have strong relation with Satisfaction of customerlclient, and although in general the quality of service have good but still a lot need improvement and repair. From is fourth of the factor which most having an effect on is leadershipConstraints which still faced among others is Leadership which not yet is fully executed second, total quality execution still not yet fully become head komitmen head and staf that still found by oflioer give less dissatisfactory and non professional service to the customer/ client, third is less looked after by isfacilities and basic facilities so that not yet futilled of short examination time According to TQM theory tht is new paradigm, head have to assume subordinate is cutomer/client which must be listened by sigh and hislits suggestion so that reaching of communications which either through horizontal and is vertical.Thats fourth of factor above in the reality most having an effecton in satisfaction of customer/client is leadership. lf leadership have been executed bette, officer will work hardly and hold responsible and have komitmen to be able to fulfill short time which specified by NADFC and service as according to quality service so that can reach by satisfaction in NADFC.