Santalun album L is one type of specifict plants growing in Timor Tengah Selatan District on Nusantenggara Timur province. This plants is also highly valuable source asset and is one of the biggest contributors in decades before 1998 for original local income thus becoming an icon in this area. Since 1960 until 1996 extreme exploitation had been resulting in deforestation of this plant. Many regulations have been made and implemented; including Regional Regulations of Timor Tengah Selatan district No. 25 in 2001 of Santalun album L purposefully for this plant to be conserved. The result of observation is estimated that implementation of the policy of Santalun album L has not been optimum so that efforts to increase this plant population have not been meet expectations. The background of problems is then explored and analyzed how much the implementation of this policy has influences on the effectiveness of conserving Santalun album L in this area. This research involves explanatory survey method in quantitative design, and uses path analysis. The result of investigation shows that the implementation has significantly proven to have influences on this plant conservation, however,the interpretation of the three has the highest influence on the effectiveness of conservation, while the application dimension has the lowest influence on this effectiveness. It is stated that the application dimension shows one condition that has not been optimal in implementation; therefore,it is to be a challenge in improving the effectiveness of this plant in the future. The result also shows that there are other findings contributing to policy implementation theory that is society participation and values both of appartus and society as the key to successful conservation of Santalun album L in Timor Tengah Selatan district of Nusa Tenggara Timur province.