The paradigm of Evidence Based Medicine (EBM) is new in the world of medicine and is used in practice praxis and medical research through a systematic observation, standardized, and objective. The article brings to light whether EBM and the supportive apparatus are able to defend the theory of decision-making concept of Pellegrino and Thomasma and how it affects the attitude of the practitioners in making a well-thought decision to administer a rational, objective, and effective treatment for the patients.