At present time, the augmentation of "regionalism" has become a striking feature of international economic relations. The motives toward regionalism itself are complex: a belief that economic integration through regionalism is conducive to growth, disillusionment with the framework for global integration, or simply a defensive reaction to the formation or reinforcement of other trading blocs. Regionalism does not merely embrace economic perspective since it also emphasizes on the cultural, social, and political aspects of human existence. This writing calls for an analysis of the paths which Indonesia chooses in pursuing its policies and objectives in the greatly dynamic regionalism and international economic framework. This writing restricts its scope on three domains of observation: ASEAN, APEC, and G20 and beyond.