Telah dilakukan penelitian tentang profile teofilin dalam plasmadan urine setelah pemberian.peroral ka psul teofilin yang berisi 300my teofilin..Penelitian tersebut dilakukan terhada p 12 orang sukarelawanyang sehat, berat badan berkisar antara 47 sampal 58 kg. umurberkisar antara 17 sam pai 28 tahun. Pengambilan darah dilakukansebelum obat diberikan, 60, 120, 180, 240, 360, 480 menit setelahohat diminum. Urine dikump ulkan pada interval waktu tertentu selama48 jam. Konsentrasi teofilin daiarn plasma dan urine ditetapkan secaraspektr ofotometri.Dari hasil penelitian didapatkan kadar terapi teofilin dalamplasma dapat dicapal dengan pembenian 300 my teofilin. Ada hubunganantara profil teofilin dalam plasma dan urine dimana waktu untukmencapai ekskresi puncak.teofilin dalam urine sama dengan waktu untukmencapai kadar puncak teofilin dalam plasma pada t mid. Jugadiperoleh parameter-parameter farmakokinetik seperti waktu oaruhteofilin (1 1/2), tetapan kece patan eliminasi (Ke), tetapankecepatanabbsorpsi (Ka) dan ekskresi teofilin dalam urine kumulatif.

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The studies of theophylline profile in plasma and urine after

given theophylline orally capsule which contain 300 mg theophylline -

has been carried out.

The studies involved twelve healthy male volunteers, the range

of body weight are beetwen 47 to 58 kg and the ages are between 17 to

28 years old. Blood samples were taken right before the drug was

administered and 60, 120, 180, 240, 360, 480 minutes after that.

Urine samples were collected at regular intervals over 48 hour

periods. The concentration of theophylline in plasma and urine

samples were determined by spectrophotometric method.

From the data obtained, we observed that the therapeutic

concentration of theophylline was reached after given 300 mg

theophylline. There was relationship between theophylline profile in

plasma and urine, in which the time needed to reach the maximum

theophylline excreation in urine was same as the time needed to reach

the maximum theophylline plasma concentration at t mid. From the data

we also observed the pharmacokinetic parameters as the half ii:fe-

(T1/2) elimination rate constant ( Ke ), absorption rate constant (

Ke ) and cumulative urinary excretion.