Jengkol <'Pi thecolobium -i iringa (Jack) Prain. ex King.)merupakan salah satu tanaman yang digunakan sebagai obattradisional, tetapi sampai saat ini belum banyak penelitianilmiah terhadap tanaman jengkol. Salah satu efek tanamanjengkol yang banyak digunakan di masyarakat adalah untukpenyakit diabetes mellitus. Penelitian ini dilakukan untukmengetahui apakah ada efek hipoglikemik papagan kulitbatang pohon jengkol pada kelinci dengan metode testoleransi glukosa secara oral.Papagan kulit batang pohon jengkol diberi secara oraldengan menggunakan sonde lambung. Kelinci dibagi atas 4kelompok. Kelompok pertama diberi air dengan volumepemberian 1 ml/kg BB, kelompok kedua diberi suspensitolbutamid 250 mg/kg BB, kelompok ketiga diberi rebusanpapagan kulit batang pohon jengkol konsentrasi 10% b/vdengan dosis 1 ml/kg BB, kelompok keempat diberi ekstraketanol papagan kulit batang pohon jengkol konsentrasi' 200%b/v dengan dosis 1 ml/kg BB. Toleransi glukosa kelincipercobaan yang diberi papagan kulit batang pohon jengkoldibandingkan dengan toleransi glukosa kelinci percobaanyang diberi air sebagai kontrol.Hasil statistik memperlihatkan rebusan papagan kulitbatang pohon jengkol tidak memperlihatkan efek hipoglikemikAyang bermakna, kecuali pada jam ke 3 terhadap kelompokkontrol dan pada jam ke 4 terhadap kelompok ekstrak etanol.

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Jengkol t-.hftf>n1obium iiringa (Jack) Prain. ex King.)

has been used as a traditional medicine, but so, far it has

not been proved scientifically. It is used empirically for

the treatment of Diabetes mellitus. Therefore this

experiment has been carried out to know whether jengkol

stem barks has actually the antidiabetic effect.

In this experiment 24 rabbits were used, these animals

were induced by 1 ml/kg body weight using 50% glucose

solution. The first group was received 2 ml/kg body weight

water as a control group, the second group was given 250 mg

tolbutamid per kg body weight as a standard treatment

group, the third group received 1 ml jengkol stem barks

boiled solution 10% wieght/volume (w/v) per kg body weight

and the fourth group was given jengkol stem barks ethanol

extract 200% w/v in dose of 1 ml per kg body weight. Those

preparation were given orally using intragastric tube. The

blood glucose level were measured by glucose tolerance test

using double beam spectrophotometers at 1, l^/s, 2, 3, 4

dan 5 hours after treatments.

The datas were statistically analysed using anova and

followed by tukey test. Stem barks boiled solution did not

show hipoglikemic effect significantly differrence from

other treatments at those observation interval except at +3

A

hours was significantly different from control group and +5

hours from ethanol extract group.