Dewasa mi gentamisin masih inerupakan obat yang pentinguntuk mengatasi infeksi berat kuman gram negatif; Karena batas keamanan gentamisin sempit maka hal ml merupkrn masalah dalam penggunaannya. Telah dilakukan pengukuran kadar gentamisin dalam serum dari 16 orang penderita pasca bedah di Bagian Kebidanan 115CM. Setiap penderita disuntikkan 80 mg gen,tamisin secara intramuskuler setiap 12 jam,selama 5 hari.pengambilam--.saxpel'.'dila kukan pada saat sebeluzn d.isuntikkan,3- jam,1 jam, 13- jam,3jam.,8 jam, 12 jam seteiah pemberian dan sesaat sebelum diberikan dosisPenentuan kadar gentamisin dalam serum dilakukan dengan cara difusi agar menurut Sabath 1930 (26) ,yang telahfikasi. Basil pengukuran yang diperoleb kemudian dicari kadar puncak dan dihiung waktu paruh gentamisin dalam serum, Dari penelitian ini didapatkan kadar puncak yang bervariasiantara 2,6 santpai 9,3 mcg/ml, ditemukan kadar subtera-peutik pada 2 penderita, waktu paruh rata-rata 2,4 jam dengan variasi antara 1 1,6 sampai Li.,6 jam. Dengan cara dan dosis yang lazim digunakan saat mi di. Bagian Kebidanan RSCM tidak ada kecenderungan terjadi toksisitas a k i b a t kumulasi, tetapi pada sebagian penderita tampaknya kadar terapeutik tidak tercapai.

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Gentaniicin is still an important drug to overcome serious

infections due to gram-negative pathogens.The narrow mar

gin of safety of this drug raises proble!n in its therapeutic

uses.

Serum levels of gentanilcin were determined from 16 post

operativepatients in the Gynaecological Department of RSCM

Each patient was given intramuscular injection of 80 mg of

gentainicin every 12 hours for five days.Blood sampling was

done at the moment before injection and half, one, one and a

half, three, eight, twelve hours after administration and at

the moment before the last dose was given.

Gentaniicin level in the serum was determined using modi

fied agar diffusion assay according to Sabath 1980 (26).

From the result of the measurement the peak level was detected

and calculation of half-life inerum was done. Peak level between 2,6 and 9,3 mc/m1 were obtained from this studies in which two-patients.--showed subtherapeutic

levels.The mean of half-life was 2,4 hours ; range between

1,6 and 4,6 hours. It is concluded that this dose regimen does not likely to cause accumulation of drug. It may otherwise gives subtherapeut.ic levels.