Penelitian mengenai kualitas Sungai Pesanggrahan telah dilakukan di sembilan stasiun pengamatan di sepanjang sungai. Penelitian ini bertujuan untuk mengetahui kualitas sungai dengan menggunakan makroozoobentos sebagai objek yang diteliti dan Biological Monitoring Working Party -- Average Score Per Taxon (BMWP -- ASPT) sebagai metode yang dipakai. Identifikasi sampel dilakukan di Laboratorium Ekologi, Jurusan Biologi, FMIPA, Universitas Indonesia. Dari hasil penelitian didapatkan 13 Famili makrozoobentos antara lain Hydropsycidae, Libellulidae, Aeshnidae, Lestidae, Chironomidae, Palaemonidae, Potamoidea, Viviparidae, Ampullaridae, Thiaridae, Corbiculidae, Tubificidae, Hirudinae, dan Glossiphoniidae. Nilai (Average Score Per Taxon) ASPT berkisar antara 1--4,75. Berdasarkan nilai ASPT terlihat bahwa Sungai Pesanggrahan dari Hulu (Bogor, Jawa Barat) sampai Hilir (Kembangan, DKI Jakarta) telah mengalami pencemaran tingkat sedang sampai berat, dengan ditandai adanya pencemaran organik dan anorganik yang tinggi.

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Research on the quality of the Pesanggrahan River has been performed in nine observation stations along the river. This study aims to determine the quality of the river using makroozoobentos as the object and Biological Monitoring Working Party -- Average score per taxon (BMWP -- ASPT) method. Identification of samples was conducted in Laboratory of Ecology, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia. There are 13 Families of makrozoobentos: Hydropsycidae, Libellulidae, Aeshnidae, Lestidae, Chironomidae, Palaemonidae, Potamoidea, Viviparidae, Ampullaridae, Thiaridae, Corbiculidae, Tubificidae, Hirudinae, and Glossiphoniidae. Value of ASPT (Average Score Per Taxon) ranged from 1--4.75. Based on the value of ASPT, the Pesanggrahan River from Upstream (Bogor, West Java) to Downstream (Kembangan, DKI Jakarta) has been experienced moderate to high level of pollution with indication of high organic and inorganic pollution.