Aim: To investigate the expression CD4+ T cell and CD8+ T cell as well as TNF-a and INF-7 level on Citron ic hepatitis C. Methods: This is a cross-sectional study. Forty patients with chronic hepatitis C based on laboratory examination, who were collected from blood transition centers at Dn M. Djamil Hospital. The control group used forty healthy samples. Results: There were 40 chronic hepatitis C cases satisfying the inclusion criteria. We found that CD4+ T cells count 50.35 + 3.1 8%; CD8+ T cells count 59.37 + 3.52%; TNF-a level 22.03 :t 3.?2 pg/ml and INF-7 level 4.47 + 1.47 pg/ml. Conclusion: The chronic infection hepatitis C virus have given the effects on the immunocompetent cells which increased of CD4+, CD8+, TNF-a level and INF-y level.