ABSTRAK
Indonesia sering dilanda bencana sehingga memerlukan pangan darurat yang dapatsegera dikonsumsi oleh korban bencana. BPPT membuat pangan darurat yangmudah dikonsumsi, bernutrisi tinggi, dan mengandung ekstrak polifenol buahdelima yang diharapkan meningkatkan sistem imun. Efek pangan daruratdibandingkan dengan ekstrak Phyllanthus niruri, imunostimulan di pasaran, padamencit kelaparan yang diberi pajanan tetanus toksoid (TT). Digunakan 30 ekormencit betina yang dibagi ke dalam dua kelompok perlakuan secara random.Observasi dilakukan sebelum perlakuan (minggu ke-0), ke-4, dan ke-8 setelahperlakuan. Pajanan TT diberikan pada akhir minggu ke-4. Pada minggu-minggutersebut, enam ekor mencit dari tiap kelompok dikorbankan untuk diambil sampeldarahnya dan dihitung jumlah dan jenis leukosit, serta kadar IgG total dan IgGspesifik anti-TT. Tidak terdapat perbedaan bermakna pada jumlah dan jenisleukosit (kecuali batang), serta kadar IgG total antarkelompok perlakuan. Terdapatperbedaan bermakna pada jumlah batang dan kadar IgG spesifik anti-TTantarkelompok perlakuan pada minggu ke-8 dengan p = 0.032 dan 0.008, yaitujumlah batang lebih tinggi pada kelompok uji dan kadar IgG spesifik anti-TT lebihtinggi pada kelompok ekstrak Phyllanthus niruri. Dapat disimpulkan bahwapangan darurat BPPT berefek hampir sama dengan ekstrak Phyllanthus niruriterhadap respon imun. Tetapi, pangan darurat lebih meningkatkan jumlah batangdan ekstrak Phyllanthus niruri lebih meningkatkan kadar IgG spesifik anti-TTsecara signifikan.

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Abstract
Indonesia is often hit by disasters that require emergency food that can beimmediately consumed by disaster victims. BPPT makes emergency food thateasily consumed, has high nutrition, and has pomegranate?s poliphenol extractthat is expected increasing immune system. The effect of BPPT?s emergency foodis comparised with the effect of Phyllanthus niruri extract as immune stimulant onthe market to hungry mice that are challenged by tetanus toxoid (TT). Thirty miceare divided randomly into two treatment groups. Mice are observed beforetreatment (week-0), in the fourth week, and eight week after treatment. TTchallenge is given in the end of fouth week. In these weeks, six mice from eachgroup are sacrificed for taking blood samples, counting the amount anddifferential counts of leukocytes, and the levels of total IgG and antitetanus-toxoidspecificIgG. There is no significant difference in the amount and differentialcounts of leukocytes (except stab), and the levels of total IgG between twotreatment groups. There are significant differences in the amount of stab andantitetanus-toxoid-specific IgG in eighth week with p = 0.032 and 0.008, BPPT?semergency food group reaches higher position in stab and Phyllanthus niruriextract group reachs higher position in antitetanus-toxoid-specific IgG . It can beconcluded that the effect of BPPT?s emergency food is almost same with the effectof Phyllanthus niruri extract on immune system. But, BPPT?s emergency foodgroup reaches higher position in stab and Phyllanthus niruri extract group reachshigher position in antitetanus-toxoid-specific IgG significantly.