Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

The free radical scavenging and anti-hyperglycemic activities of various gambiers available in Indonesian market

Galuh Widiyarti, Andini Sundowo, Muhammad Hanafi ([Direktorat Riset dan Pengabdian Masyarakat UI;Lembaga Ilmu Pengetahuan Indonesia (LIPI);Lembaga Ilmu Pengetahuan Indonesia (LIPI), Lembaga Ilmu Pengetahuan Indonesia (LIPI)], 2011)

 Abstrak

ABSTRACT
Gambier (Uncaria gambier) is known to have antioxidant properties, and some studies have attributed it to the presence
of polyphenols such as catechin. The objective of this study is to investigate the potential of various gambiers available
in Indonesian market as a scavenger of reactive free
radicals and evaluate its anti-hyperglycemic activity as α-glucosidase inhibitor. Isolation of catechin was done by extraction method with technical grade of ethyl acetate as solvent. Analysis of catechin in the dried gambier extract was carried out with TLC method. The molecular weight and content of catechin of dried gambier extract was determined by analyzing its mass spectra and spectrophotometer,
respectively. The free radical scavenging activity of catechin of the resultant extracts was measured by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) as stable free radical compound. The anti-hyperglycemic activity of catechin of ethyl acetate extracts was analyzed as α-glucosidase inhibitor. The result showed that various gambiers available in the
market are very active as antioxidant, indicated by IC50
of catechin of ethyl acetate extracts which were 4.6 to 18.2μ
g/mL for DPPH inhibition. The IC50 for α-glucosidase inhibition is ranged from 40.45 to 52.43μ g/mL, so they can be classified as anti-diabetic.

 Metadata

Jenis Koleksi : Artikel Jurnal
No. Panggil : J-Pdf
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Subjek :
Penerbitan : [Place of publication not identified]: [Direktorat Riset dan Pengabdian Masyarakat UI;Lembaga Ilmu Pengetahuan Indonesia (LIPI);Lembaga Ilmu Pengetahuan Indonesia (LIPI), Lembaga Ilmu Pengetahuan Indonesia (LIPI)], 2011
Sumber Pengatalogan : LibUI eng rda
ISSN : 23391995
Majalah/Jurnal : Makara : Sains
Volume : Vol. 15, No. 2, November 2011: 129-134
Tipe Konten : text
Tipe Media : unmediated
Tipe Carrier : volume
Akses Elektronik : http://journal.ui.ac.id/index.php/science/article/view/1062/975
Institusi Pemilik : Universitas Indonesia
Lokasi : Direktorat Riset dan Pengabdian Masyarakat UI
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J-Pdf 03-19-320288165 TERSEDIA
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