ABSTRAKTujuan: Mengetahui kesintasan hidup, respon pengobatan dan faktor yang mungkin
mempengaruhi dalam penanganan karsinoma nasofaring stadium lokal lanjut
Metode: Dilakukan penelitian retrospektif deskriptif analitik terhadap 391 pasien
karsinoma nasofaring stadium lokal lanjut yang berobat di Departemen Radioterapi
RSCM periode Januari 2007-Desember 2011, dilihat karakteristik pasien maupun
tumor. Analisis kesintasan dihitung dengan kurva Kaplan Meier dan respon radiasi
dianalisa menggunakan uji korelasi Spearman pada pasien yang memenuhi kriteria
inklusi.
Hasil: Didapatkan 70.6% pasien adalah laki laki, median usia 45 (9-86) tahun.
Sebagian besar stadium IVB (32,7%) dengan tipe histopatologis WHO III paling
dominan (82,4%) Kesintasan hidup 3 dan 5 tahun untuk masing-masing stadium IIB,
III, IVA, IVB berturut-turut adalah 64,9%, 57,6%, 47,4%, 48,0% dan 64,9%, 43,2%,
34,3%, 26,6%. Sedangkan respon komplit untuk masing-masing stadium IIB, III,
IVA, IVB berturut-turut 83,3%, 73,3%, 52,6%, 45,8%. Terdapat korelasi bermakna
antara respon radiasi dengan stadium (r=0,242;p=0,038) dan antara respon radiasi
dan kesintasan hidup (r=-0,251;p=0,031).
ABSTRACTPurpose: To show the overall survival rate, radiation response and factors influenced
on locally advanced nasopahryngeal cancer.
Method: Retrospective analytic descriptive study of 391 newly diagnosed locally
advanced nasopharyngeal cancer patients from January 2007 till December 2011, to
show their characteristics. Overall survival rate were analyzed by Kaplan Meier
Survival curve and the radiation response correlation with other factors were
analyzed by Spearman correlation test.
Result: Most of the subjects are male (70.6%), with median age 45 (9-86) years old.
Mainly on stage IVB (32,79%) with the most hystopalogic was type III WHO
(82,4%). All of the subjects were analyzed for 3 and 5 years overall survival, resulted
for stage IIB, III, IVA, IVB were 64,9%, 57,6%, 47,4%, 48,0% dan 64,9%, 43,2%,
34,3%, 26,6% respectively. Complete respons for stage IIB, III, IVA, IVB were
83,3%, 73,3%, 52,6%, 45,8%, respectively. There were significant correlation
between radiation response and cancer stadium (r=0,242;p=0,038) and between
radiation response with overall survival rate (r=-0,251;p=0,031).