Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Uji stabilitas sediaan mikroemulsi menggunakan hidrolisat pati (DE 35-40) sebagai stabilizer

([Fakultas Farmasi Universitas Indonesia, Universitas Indonesia], 2006)

 Abstrak

Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was
made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability
of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35?40 as stabilizer, and water as external
phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%.

 Metadata

Jenis Koleksi : Artikel Jurnal
No. Panggil : pdf
Subjek :
Penerbitan : [Place of publication not identified]: [Fakultas Farmasi Universitas Indonesia, Universitas Indonesia], 2006
Sumber Pengatalogan :
ISSN :
Majalah/Jurnal : Majalah Ilmu Kefarmasian
Volume : Vol. 3, No. 1, April 2006: 8-21
Tipe Konten :
Tipe Media :
Tipe Carrier :
Akses Elektronik : http://journal.ui.ac.id/index.php/mik/article/view/1156/1063
Institusi Pemilik : Universitas Indonesia
Lokasi : Fakultas Farmasi Universitas Indonesia
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