Carbon monoxide (CO) poisoning is the most common of all poisoning in industries today and is responsible for over half of the poisoning fatalities reported each year in The United State. However, in Indonesia is not data or report according to Carbon monoxide poisoning eventhough its founded in some area incidently. But, if Indonesia become industrial country, we may make prediction which this problems will get improve and become greater than today. There are some report today according to deadness related to carbon monoxide poisoning. For example, persons are dead in garage in which ingine of car is on and some people dead in building that is fire. The people dead is as a result of carbon monoxide poisoning. Carbon monoxide poisoning occur too much caused by some reasons. The possibilities of carbon monoxide poisoning are ambiquitous. It has colorless and odorless. Therefore, gives no warning of its presence under any circumstance. In addition, almost all of industrial toxins have characteristic odor, taste or appearance or produce some sort of irritation that warns the potensial victim, a factor not present in carbon monoxide poisoning. Another reason that makes this form of poisoning particularly insidous is that the early sympthoms can resemble other diseases. But the same with other diseases like nausea, headache and dizziness ect. So that the persons who has carbon monoxide poisoning found by wrong diagnosis and has fatal impact. Beside this that also has been senses CO poisoning can cause muscle weakness so that the victim will not be able to get out from poison resources area eventhough they know hazardous matter coming up to them.