Dengue Hemorrhagic Fever (DBD) has become public health problem for almost four decades. The highest case took place in DKl Jakarta than the other provinces till year 2007 which 30.703 of overall eases, 82 of mortality case, IR (378.5) and CFR (0.3). The South Jakarta is the highest ease in DKI Jakarta which are 28 of mortality case, IR (551.69), CFR (0.3), tends to increase for every years.Consequently related study of risk factors of DBD case must be took using new technology of Geographic Information System (GIS) contributed fur mapping correspond to examination, analysis. and controlling of health services. This study aimed to obtain description of epidem tology of DBD based on Geographic Information System (GIS) and related factors oi DBD case taking place in South Jakarta year 2007. Design of research uses ecological and serial of case study exploiting secondary data in Sudinkesmas, BPS Jakarta, and BMG. The data was analyzed in the manner of univariat, bivariat, multivariat and spatial. Result of research of DBD case in South Jakarta on January - December 2007 found most man hit by this case about 53,9%, partially age of 5-14 years old with 26% proportion and 15-44 years old with 55%. The highest incident rate of 64 sub-districts is Mampang Prapatan with 1225/100.000 population. While the lowest incident rate found in Pasar Minggu sub-district with 3941100.000. Generally top of epidemy happened on February and March.