ABSTRAK
Tujuan penelitian ini adalah untuk mengetahui efek pamberian bubuk susu kedelai2x30 gramlbari, selama 8 minggu terhadap kadarkolesterol LDL dan HDL serum pada wanitaparimenopauseBertempat di Klinik Seruni Departemen Ilmu Gizi Fakultas KedokteranUniversitas lndnesia, jalan Salemba Raya no.6, JakartaPenelitian dengan rancangan one group pre-post tes yangtelah disetujui Komite Etik FKUI. Subyek mendapatsuplementasi susu bubuk kedelai 2x30 g/hari selama 8minggu. Pada awal (minggu 0); pertengahan (minggu IV);dan akhir penelitian ( awal minggu IX) dilakukanpemeriksaan kadar kolesterol LDL dan HDL. Data isilpanzat gizi dilukukan sebelum dan selama penelitianberlangsung, dengan menggnnakan food recall l x24 jam.Uji statistik yang digunakan adalah uji t berpasangan jikadata berdistnbusi normal dan Wilcoxon, jika databerdistribusi tidak normal. Tingkat kemaknaan yangdigunakan p<0,05.Sebanyak 19 subyek penelitian yang dapat mengikutipenelitian sampai selesai. Setelah delapan mingguperlakuan, didapatkan adanya penurunan yang bermakna(p<0,05) pada kadar kole-ol LDL, yaitu sebesar8,59±17,31% di minggu IV dan 7,81±11,32% di minggu IX.Kadar kolesterol HDL menurun pada minggu IV dan IX,namun tidak bermakna (p>0,05). Rasio kolesterol LDLterhadap HDL, men= secilla bermakna (p<0,05) diminggu IV, yaitu sebesar 7,03±16,82%, sedangkan diminggu IX terjadi penurunan, namun tidak bermakna(p>0,05), sebesar 4,04±12,25%.Pemberian bubuk susu kedelai 2x30 g/hari selama delapanminggu, dapat menurunkan kadar kolesterol LDL sertarasio LDLIHDL secara bermakna.

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Abstract
This research aim to investigate the effects of2x30 lifd soy milk flour, for eight. weeks on serumo cholesterol LDL andHDL levels inhypercholesterolemic perimenopausal womenLocated at Seruni Clinic, Depar1ment of Nutrition, Faculty of MedicineUniversity of IndonesiaThe study was a one group pre-post test design, which wasapproved by The Ethical Clearance Research Committee ofFaculty of Medicine University of Indonesia. The subjectsreceived 2x30 g/d soy milk powder for eight weeks. Serum LDLand HDL cholesterol levels were determined at the heghming(week 0), the middle (week4), and the end of the stndy(earlyweek 9). Dietery intakes were assessed using lx24 hours foodrecall. Statistical analysis was performed using dependent t tesfor normal distribution and Wilcoxon for not normal distributiondata. The level of significancy was 5% (p<0,05)There were 19 subjects who completed the study. After eightweeks intervention, there was 8.59±17.31% significant decreasedin LDL cholesterol levels at the 4th week of the study and7.81±1 1.32% at the s"' week of the study (p<0,05).HDLcholesterol levels decreased at the 4\h and 8" weeks, but notsignificant(p>0,05). The ratio ofLDL to HDL was 7,03±16,82o/o,which was significant decreased at the 4" week (p<0,05), while atthe 9th week the decrement was not significant (4.04±12.25%),p> 0.05.Consuming soy milk powder 2 x 30 g/dduring eight weeks, canreduce the LDL cholesterol level and LDLIIIDL ratiosignificantly.