ABSTRAKBanyak studiBanyak studi epidemiologi, klinis dan in vitro terakhir menunjukkan hubungan antara vitamin
D dengan tuberkulosis (TB) paru. Kadar 25-hidroksivitamin D (25(OH)D) yang rendah
berhubungan dengan penyakit TB paru aktif dan laten. Namun, sampai saat ini belum ada data
mengenai hubungan kadar 25(OH)D dan status vitamin D dengan derajat lesi TB paru. Tujuan
penelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dan
kadar 25(OH)D dengan derajat lesi TB paru ringan, sedang dan berat. Desain penelitian
potong lintang, terdiri dari 137 pasien TB paru terbagi menjadi kelompok derajat lesi TB paru
ringan, sedang dan berat masing-masing 46, 47 dan 44 pasien. Diagnosis TB paru
berdasarkan Pedoman Nasional Pengendalian Tuberkulosis, Kementerian Kesehatan Republik
Indonesia. Derajat lesi TB paru dinilai secara radiologis berdasarkan klasifikasi dari National
Tuberculosis and Respiratory Disease Association, New York. Status vitamin D ditetapkan
menurut rekomendasi Holick. Pada ketiga kelompok dicatat data karakteristik subjek dan
dilakukan pemeriksaan 25(OH)D. Status vitamin D pada subjek penelitian ini didapatkan
sebanyak 122(89,1%) defisiensi dan 15(10,9%) insufiensi vitamin D. Proporsi defisiensi dan
insufisiensi vitamin D kelompok TB paru ringan, sedang dan berat tidak didapatkan
perbedaan bermakna, masing-masing dengan 84,8% dan 15,2%; 91,5% dan 8,5%; 90,9% dan
9,1%. Kadar 25(OH)D kelompok TB paru ringan, sedang dan berat tidak berbeda bermakna,
masing-masing dengan rerata 12,96 (SB±5,83)ng/mL, 12,42 (SB±5,13)ng/mL, dan 11,29
(SB±5,61)ng/mL. Kami menyimpulkan status vitamin D dan kadar 25(OH)D tidak
berhubungan dengan derajat lesi TB paru. Proporsi defisiensi dan insufisiensi vitamin D
kelompok TB paru ringan, sedang dan berat tidak didapatkan perbedaan bermakna, masingmasing
dengan 84,8% dan 15,2%; 91,5% dan 8,5%; 90,9% dan 9,1%.
ABSTRACTMost recent epidemiological, clinical and in vitro studies indicate that there is a the
relationship between vitamin D and pulmonary tuberculosis (TB). Low concentration of 25-
hydroxyvitamin D (25(OH)D) is associated with active and latent pulmonary TB disease.
Nevertheless, there is no data about the relationship between vitamin D status and
concentrations of 25(OH)D with severity of pulmonary TB. The aim of this study was to
obtain the relationship between proportions of vitamin D and concentrations 25(OH)D with
mild, moderate and severe degrees of pulmonary TB lesions. This was a cross-sectional study,
137 patients with pulmonary TB and 46, 47 and 44 patients each of mild, moderate and severe
degree of pulmonary TB lesions, respectively. Diagnosis of pulmonary TB was based on
National Tuberculosis Control Guideline, Ministry of Health of the Republic of Indonesia.
The degree of pulmonary TB lesion was radiologically assessed based on classifications of the
National Tuberculosis and Respiratory Disease Association, New York. Vitamin D status was
defined according to Holick recommendations. Baseline characteristics of subjects were
recorded and 25(OH)D concentrations were measured in subjects of each groups. Vitamin D
status of the subjects were 122 (89.1%) deficiency and 15 (10.9%) insufficiency of vitamin D.
The proportions of vitamin D deficiency and insufficiency at mild, moderate and severe
degree of pulmonary TB lesions were also not significantly different, i.e. 84.8% and 15.2%,
91.5% and 8.5%, 90.9% and 9.1%, respectively. Concentrations of 25 (OH) D in each group
of mild, moderate and severe pulmonary TB lesions were not significantly different, with a
mean (SD) 12.96 (5.83)ng/mL, 12.42 (5.13)ng/mL, and 11.29 (5.61)ng/mL respectively. It is
concluded that vitamin D status and serum 25 (OH) D were not related to the degree of
pulmonary TB lesion. The proportion of vitamin D deficiency and insufficiency at mild,
moderate and severe degree of pulmonary TB lesions were also not significantly different, i.e.
84.8% and 15.2%, 91.5% and 8.5%, 90.9% and 9.1%, respectively.
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