[
ABSTRAKBPPT (Badan Pengkajian dan Penerapan Teknologi) memproduksi suatu bahan
pangan padat gizi mengandung polifenol, yang ditujukan bagi korban bencana
alam yang rentan akan kondisi penurunan respon imun akibat kelaparan.
Polifenol, pada beberapa penelitian disebutkan dapat meningkatkan respon imun.
Sebelum dikonsumsi, perlu dilakukan penelitian untuk melihat bukti efektivitas
pangan ini terhadap respon imun. Penelitian dilakukan dengan menggunakan
desain eksperimental. Sebanyak 24 mencit dibuat dalam kondisi lapar selama satu
minggu. Lalu 6 ekor mencit diambil datanya sebagai acuan kondisi awal.
Kemudian sisa mencit dibagi dalam tiga kelompok perlakuan. Setiap kelompok,
tetap dalam kondisi lapar, akan mengonsumsi bahan tambahan yang berbeda.
Kelompok pertama diberikan produk pangan padat gizi mengandung polifenol,
sedangkan kelompok kedua diberikan produk pangan padat gizi tanpa polifenol,
untuk melihat apakah polifenol memang mempunyai efek atau produk pangan
padat gizi saja sudah dapat meningkatkan respon imun. Sebagai tambahan
perbandingan, maka kelompok ketiga diberikan imunostimulan Phyllanthus
niruri. Setelah 4 minggu dilakukan pengambilan data. Sebagai indikator respon
imun digunakan data jumlah dan hitung jenis leukosit. Hasil penelitian
menunjukkan bahwa tidak ditemukan perbedaan yang bermakna (p>0,05) pada
perbandingan perubahan jumlah leukosit dan hitung jenisnya dari ketiga
kelompok perlakuan. Disimpulkan bahwa bahan pangan padat gizi mengandung
polifenol belum menunjukkan bukti efektivitas yang lebih tinggi terhadap respon
imun dibandingkan tanpa mengandung polifenol, namun bahan pangan padat gizi
ini sudah cukup baik karena menghasilkan efek seperti imunostimulan
Phyllanthus niruri.;
ABSTRACTBPPT (Badan Pengkajian dan Penerapan Teknologi) produced a nutrient-rich food
product with polyphenols, for disaster victims that vulnerable to condition of
depressing immune response because of starvation. Polyphenols, in some research
could enhance immune response. Before applying, this food product needs a
research to prove the effectiveness toward immune response. Research was done
with experimental design. 24 mices set in starving condition in one week. Then 6
mices were taken to get the beginning data. And then, the rest of mices was
divided into three groups. Every group, stayed in starving condition, was given
different additional materials. First group was given the nutrient-rich food product
with polyphenols, and the second group was given the nutrient-rich food product
but without polyphenols, to see whether the polyphenols gave the desired effect or
the nutrient-rich food product alone could enhance immune response. For
additional comparison, the third group was given the immunostimulant
Phyllanthus niruri. The data was taken after 4 weeks. Total leukocyte and
leukocyte differential count were used to be the indicator of immune response.
The result showed that there is no significant differences (p>0,05) in comparison
of the change of total and differential count of leukocyte from the three groups. In
conclusion, the nutrient-rich food product with polyphenols not yet show a
significant effectiveness in immune response than without polyphenols, but this
food product had been good enough because resulting the similar effect as
immunostimulant Phyllanthus niruri., BPPT (Badan Pengkajian dan Penerapan Teknologi) produced a nutrient-rich food
product with polyphenols, for disaster victims that vulnerable to condition of
depressing immune response because of starvation. Polyphenols, in some research
could enhance immune response. Before applying, this food product needs a
research to prove the effectiveness toward immune response. Research was done
with experimental design. 24 mices set in starving condition in one week. Then 6
mices were taken to get the beginning data. And then, the rest of mices was
divided into three groups. Every group, stayed in starving condition, was given
different additional materials. First group was given the nutrient-rich food product
with polyphenols, and the second group was given the nutrient-rich food product
but without polyphenols, to see whether the polyphenols gave the desired effect or
the nutrient-rich food product alone could enhance immune response. For
additional comparison, the third group was given the immunostimulant
Phyllanthus niruri. The data was taken after 4 weeks. Total leukocyte and
leukocyte differential count were used to be the indicator of immune response.
The result showed that there is no significant differences (p>0,05) in comparison
of the change of total and differential count of leukocyte from the three groups. In
conclusion, the nutrient-rich food product with polyphenols not yet show a
significant effectiveness in immune response than without polyphenols, but this
food product had been good enough because resulting the similar effect as
immunostimulant Phyllanthus niruri.]
