[Karya Ilmiah Akhir ini bertujuan untuk menjelaskan seluruh rangkaian kegiatan praktik residensi keperawatan medikal bedah dalam memberikan asuhan keperawatan pada pasien dengan berbagai macam gangguan sistem persarafan dengan pendekatan teori Adaptasi Roy, kegiatan penerapan evidence based nursing practice berupa efektifitas penggunaan Patient Health Questionnaire 9 (PHQ-9) untuk skrining depresi pada pasien post cedera kepala dan kegiatan inovasi keperawatan berupa penggunaan Barthel Indeks untuk mengkaji status fungsional pasien. Seluruh rangkaian kegiatan tersebut diharapkan dapat meningkatkan kualitas asuhan keperawatan pada pasien neurologi dimasa yang akan datang., The purpose of this final scientific report is to describe series of activities in clinical practice residency in medical surgical nursing in providing nursing care on patient with various neurological system disorders using Roy’s Adaptation theory. Another activities includes implementation of evidence based nursing practice on the effect of Patient Health Questionnaire 9 (PHQ-9) to screen the depression level on post head injury patients, and the innovation activity was on the use of Barthel index assessment to assess patient’s functional status. From those series activities, it is expected to improve nursing care quality on patient with neurological disorder in the future.]