[Latar Belakang: Meningitis Cryptococcus merupakan infeksi oportunistikpenting pada penderita AIDS dan menduduki urutan ke tiga infeksi otak. Angkakejadian meningitis Cryptococcus secara umum sebesar 957 900 kasus per tahun.Angka kejadian di Indonesia sekitar 5-30%, dan di Jakarta sebesar 21,9%. Angkakejadian tersebut tampaknya belum mencerminkan kondisi sebenarnya, mungkinkarena gejala klinis yang tidak khas dan diagnosis pasti memerlukan cairan otakyang sulit didapat. Diperlukan metode lain untuk membantu keputusan klinis saatpungsi lumbal belum dapat dilakukan sehingga prevalensi kriptokokosis yangsesungguhnya diketahui.Tujuan: Mengetahui prevalensi kriptokokosis pada pasien terinfeksi HIV praARV di UPT HIV RSCM.Metode penelitian: Studi potong lintang dilakukan sejak Mei - Juli 2013. Subjekpenelitian adalah pasien terinfeksi HIV pra ARV. Antigen serum Cryptococcusdiperiksa dengan metode lateral flow immunoassay (LFA).Hasil: Dari 78 subjek penelitian, sebanyak 59% adalah laki-laki, berusia 18-68tahun. Kadar CD4 berkisar antara 2-754 sel/mm3, dan 68% dengan CD4 <200sel/mm3. Sebanyak lima (6,4%) subjek positif antigen serum Cryptococcus, duadiantaranya dilakukan pungsi lumbal dengan hasil tidak dijumpai Cryptococcus.Kedua subjek ini mendapat terapi flukonazol oral dan hidup sampai saat ini. Tigasubjek lain menolak tatalaksana dan meninggal empat minggu kemudian.Simpulan: Prevalensi kriptokokosis pada pasien terinfeksi HIV pra ARV di UPTHIV-RSCM sebesar 6,4%., Background: Cryptococcal meningitis is prominent opportunistic infectionsoccur in PWHIV and seats as the third most frequent brain infection. In general,Meningitis Cryptococcal reach 957 900 cases per year. It is estimated that theprevalence rate is 21.9% and 5 – 30% for Jakarta and Indonesia, respectively. Itdoes not reflect the real number, which might be due to unspecific clinicalsymptoms. In making diagnosis, it requires cerebrospinal fluid that is challengingto obtain. Other method is needed to feeding clinical decision, when lumbalpuncture cannot be performed. Thus, real Cryptococcal prevalence is known.Aim: To ascertain Cryptococcal prevalence among pre-ART PWHIV atIntegrated HIV Clinic, Cipto Mangunkusumo Hospital.Method: This study using cross-sectional design conducted from May – July2013 at the HIV clinic. Participants of the study were patients who have notstarted ART. Cryptococcal serum antigen was tested using LFA.Results: Of 78 participants, 59% male, age 18 – 68 year old. CD4 countvariedfrom 2 – 754 cell/mm3, where 68% had CD4 count <200 cell/mm3. Fiveparticipants (6.4%) were positive to Cryptococcal serum antigen, whereas two runlumbal puncture which showing negative result for Cryptoccus. They receivedoral fluconazole treatment and have survived until present. The rest refusedthetreatment and passed away four weeks later.Conclusion: Cryptococcosis prevalence among pre-ART PWHIV at IntegratedHIV clinic, Cipto Mangunkusumo Hospital is 6.4%.]