[Latar belakang. Depresi merupakan salah satu gangguan psikiatri yang seringterjadi pada pasien epilepsi. Prevalensinya adalah 20-80%. Depresi bukanmerupakan suatu pemeriksaan yang rutin dilakukan di poliklinik neurologi karenamembutuhkan waktu yang cukup lama, sehingga banyak pasien yang tidakterdiagnosis dan akhirnya tidak terobati, untuk itu diperlukan pemeriksaan yangsingkat. The Neurological Disorders Depression Inventory for-Epilepsi (NDDI-E)merupakan pemeriksaan skrining depresi yang terdiri dari 6-aitem.Tujuan. Menentukan akurasi dan titik potong NDDI-E versi Indonesia sebagaiskrining depresi pada pasien epilepsi dewasa.Metode. Penelitian uji diagnostik yang dilakukan di poliklinik epilepsi RSCM.Pemeriksaan dilakukan pada semua pasien epilepsi yang memenuhi kriteriainklusi. Pasien mengisi sendiri formulir NDDI-E tanpa bantuan orang lain.Kemudian dilakukan pemeriksaan the International Neuropsychiatric InterviewMini ICD-10 (MINI-ICD10) sebagai standar baku.Hasil. Dari 105 orang subyek penelitian terdapat 23 orang mengalami gangguandepresi mayor berdasarkan MINI-ICD 10. Didapatkan kurva Receiver OperatingCharacteristic (ROC) yang mendekati 100%, titik potong 11, dengan Sensitifitas91,3% Spesifisitas 89% PPV 70% dan NPV 97,3%. Secara statistik NDDI-E versiIndonesia masuk dalam klasifikasi yang kuat, karena nilai Area Under the Curve(AUC) 97,5% dengan interval kepercayaan (95%CI 95%-99%).Kesimpulan. NDDI-E versi Indonesia memiliki nilai akurasi yang tinggi untukmenentukan gangguan depresi mayor pada pasien epilepsi dewasa pada titikpotong 11.;Background. Depression is a common psychiatric disorder in epilepsy. Theprevalence is 20-80%. The depression is not a routinely assessed in neurologyclinics, because the assestment takes a long time. So, many patients are underdiagnosed and untreated. The Neurological Disorders Depression Inventory for-Epilepsy (NDDI-E) is a depression screening examination consist of only 6-aitem.Purpose. To determine the accuracy and cut-off point of NDDI-E Indonesianversion as a screening depression examination for adult epilepsy patients.Method. Diagnostic test study was conducted at epilepsy clinic on RSCM. All theepilepsy patient who met the inclusion criteria was examined. The patient took theNDDI-E Indonesian version as a self assesment. Then there were assest with usedthe International Neuropsychiatric Interview Mini ICD-10 (MINI-ICD10) as agold standar.Results. From the 105 subjects, there were 23 people suffered from majordepression by MINI-ICD10. Receiver Operating Characteristic (ROC) curveobtained which is close to 100%, cut-off point at 11, with Sensitivity 91.3%Specificity 89% PPV 70% and NPV of 97.3%. It was statistically classified asstrong because the value of Area Under the Curve (AUC) is 97.5% with aconfidence interval (95% CI 95% -99%).Conclusion. NDDI-E Indonesian version has a high accuracy to determine majordepressive disorder in adult epilepsy patients with the cut-off point at 11., Background. Depression is a common psychiatric disorder in epilepsy. Theprevalence is 20-80%. The depression is not a routinely assessed in neurologyclinics, because the assestment takes a long time. So, many patients are underdiagnosed and untreated. The Neurological Disorders Depression Inventory for-Epilepsy (NDDI-E) is a depression screening examination consist of only 6-aitem.Purpose. To determine the accuracy and cut-off point of NDDI-E Indonesianversion as a screening depression examination for adult epilepsy patients.Method. Diagnostic test study was conducted at epilepsy clinic on RSCM. All theepilepsy patient who met the inclusion criteria was examined. The patient took theNDDI-E Indonesian version as a self assesment. Then there were assest with usedthe International Neuropsychiatric Interview Mini ICD-10 (MINI-ICD10) as agold standar.Results. From the 105 subjects, there were 23 people suffered from majordepression by MINI-ICD10. Receiver Operating Characteristic (ROC) curveobtained which is close to 100%, cut-off point at 11, with Sensitivity 91.3%Specificity 89% PPV 70% and NPV of 97.3%. It was statistically classified asstrong because the value of Area Under the Curve (AUC) is 97.5% with aconfidence interval (95% CI 95% -99%).Conclusion. NDDI-E Indonesian version has a high accuracy to determine majordepressive disorder in adult epilepsy patients with the cut-off point at 11.]