[in orabase, sering digunakan dalam terapi stomatitis aftosa rekuren (SAR).Penelitian ini bertujuan mengetahui efektivitas sediaan baru gel bioadhesifklobetasol propionat (KP) 0,05% dengan kontrolTA 0,1% in orabase dalam terapiSAR tipe minor. Kitosan dan hydroxy propyl methyl cellulose (HPMC) digunakansebagai basis gel bioadhesif.Metode:Penelitian ini merupakan uji klinis tersamargandapada empat puluh mahasiswa Fakultas Kedokteran Gigi UniversitasIndonesia.Dua puluh subjek menggunakan gel bioadhesif KP 0,05% tiga kalisehari dan dua puluh subjek menggunakan TA 0,1% in orabase tiga kali sehari.Luas lesi dan derajat eritema SAR dievaluasi setiap dua hari dan intensitas nyeridievaluasi setiap hari.Hasil: Terjadi perbaikan klinis pada kelompok KP maupunkelompok TA dengan periode kesembuhan ≤ 6 hari. Tidak diperoleh perbedaanyang bermakna antara luas lesi, derajat eritema, dan intensitas nyeri SAR antarakelompok KP dan kelompok TA pada masing-masing haripemeriksaan.Simpulan: Dalam periode yang sama, baik gel bioadhesif KP 0,05%dan TA 0,1% in orabase menunjukkan pengurangan ukuran lesi, derajat eritema,dan intensitas nyeri SAR yang setara., Background: Topical corticosteroid such as triamcinolone acetonide (TA) 0,1%in orabase is commonly used in treatment of recurrent aphthous stomatitis (RAS).The aim of this study was to evaluatethe effectiveness of a novel clobetasolpropionate (CP) 0,05% bioadhesive gel with TA 0,1% in orabase as control inminor RAS. Chitosan and hydroxy propyl methyl cellulose (HPMC) were used asbioadhesive gel base.Methods: This study was double blind clinical trial wereinvolved forty students of Faculty of Dentistry Universitas Indonesia.Twentysubjects used CP 0,05% bioadhesive gel three times a day and twenty subjectsused TA 0,1% in orabase three times a day. Ulcer size and degree of erythemawere evaluated every two days and pain intensity was evaluated each day.Results:The administration ofCP 0,05% bioadhesive gel and TA 0,1% in orabase wereeffective in producing remission of signs and symptoms in each group of subjectswith healing period ≤ 6 days. No significant differences were found between thetwo group studied in ulcer size, degree of erythema, and painintensity.Conclusions: In the same period, both of CP 0,05% bioadhesive gel andTA 0,1% in orabase showed equal reduction of ulcer size, degree of erythema, andpain intensity.]