ABSTRAK
Penggunaan siklofosfamid sebagai agen kemoterapi menyebabkan beberapa efeksamping berupa mual, muntah, leukopenia, anemia, dan sistitis hemoragik. Efeksamping yang disebabkan oleh siklofosfamid perlu mendapatkan perhatian danpenanganan khusus karena dapat membahayakan pasien. Penelitian ini bertujuanuntuk menganalisis prevalensi kejadian mual, muntah, leukopenia, anemia, dansistitis hemoragik pada pasien kanker yang mendapatkan kemoterapisiklofosfamid di Rumah Sakit Kanker Dharmais Jakarta periode Juli 2012 – Juli2013. Metode penelitian yang digunakan adalah cross-sectional dan pengambilandata retrospektif dilakukan dengan menggunakan data rekam medik pasien.Sampel adalah pasien yang mendapatkan kemoterapi siklofosfamid di RumahSakit Kanker Dharmais Jakarta periode Juli 2012 – Juli 2013. Pengambilansampel sebanyak 79 sampel dilakukan dengan total sampling. Berdasarkan hasilpenelitian didapatkan prevalensi efek samping pada pasien yang mendapatkankemoterapi siklofosfamid di Rumah Sakit Kanker Dharmais Jakarta periode Juli2012 – Juli 2013 adalah mual (69,6%), muntah (50,6%), leukopenia (96,2%),anemia (87,3%), dan sistitis hemoragik (13,9%). Muntah dipengaruhi oleh dosis(p=0,000).

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ABSTRACT
Some of adverse drug reactions such as nausea, vomiting, leucopenia, anemia, andhemorrhagic cystitis caused cyclophosphamide as chemotherapy agents. The sideeffects caused by cyclophosphamide should get special attention and treatmentbecause it can harm the patient. This research aimed to analyze the prevalence ofnausea, vomiting, leucopenia, anemia, and hemorrhagic cystitis of patients treatedwith cyclophosphamide chemotherapy in Dharmais Cancer Hospital Jakartaperiod July 2012 - July 2013. The research design was cross-sectional andretrospective by using the patient's medical record. Samples were cancer patientswho received cyclophosphamide chemotherapy in Dharmais Cancer HospitalJakarta period July 2012 - July 2013. Sampling was carried out as many as 79samples with a total sampling. Based on the results, the prevalence of side effectsof patients treated with cyclophosphamide chemotherapy in Dharmais. CancerHospital Jakarta period July 2012 - July 2013 were nausea (69.6 %), vomiting(50.6 %), leucopenia (96.2 %), anemia (87.3 %), and hemorrhagic cystitis (13.9%). Vomiting was influenced by dose (p=0,000).