[ABSTRAK
Monosodium glutamat MSG digunakan secara luas dan tanpa takaran yang terkontrol sebagai penyedap makanan Konsumsi MSG selama kehamilan pada hewan coba menyebabkan berbagai gangguan pada janin salah satunya adalah sel otak Tujuan penelitian ini adalah mengetahui pengaruh MSG terhadap gambaran histologis otak bagian korteks serebri pusat motorik tikus yang induknya mengonsumsi MSG selama kehamilan Penelitian ini menggunakan desain eksperimental dengan cara mengamati dan menghitung sel saraf normal pada area M1 korteks serebri neonatus tikus yang induknya diberikan MSG per oral selama gestasi Sampel yang digunakan sebanyak 36 otak tikus yang dibagi menjadi empat kelompok kontrol MSG 1200 mg kg BB MSG 2400 mg kg BB dan MSG 4800 mg kg BB Hasil penelitian menunjukkan adanya pertambahan persentase sel sel saraf normal pada kelompok perlakuan dibandingkan kelompok kontrol Walaupun pertambahan ini tidak signifikan secara statistik pada kelompok MSG 1200 mg kg BB dan MSG 4800 mg kg BB uji one way Anova namun kelompok MSG 2400 mg kg BB mengalami pertambahan signifikan p.

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ABSTRACT
Monosodium glutamate MSG is widely used without any regulation or controlled doses in Indonesia MSG consumption during pregnancy on rat causes many defects on fetus especially brain neurons The purpose of this study was to determine the effect of MSG on the histology of motoric center on cerebral cortex of the rats This study design was experimental by observing and counting the normal neurons on M1 area of rat neonates rsquo cerebral cortex whose mother received MSG per oral during the gestation period This study used 36 rat brains which were divided into four groups control MSG 1200 mg kg BW MSG 2400 mg kg BW and MSG 4800 mg kg BW The result showed an increased percentage of normal neurons on MSG group compared to control group This increment is not significant statiscally on group MSG 1200 mg kg BW and 4800 mg kg BW Nevertheless on group who was given MSG 2400 mg kg BW there was a significant increased of normal neuron percentage p, Monosodium glutamate MSG is widely used without any regulation or controlled doses in Indonesia MSG consumption during pregnancy on rat causes many defects on fetus especially brain neurons The purpose of this study was to determine the effect of MSG on the histology of motoric center on cerebral cortex of the rats This study design was experimental by observing and counting the normal neurons on M1 area of rat neonates rsquo cerebral cortex whose mother received MSG per oral during the gestation period This study used 36 rat brains which were divided into four groups control MSG 1200 mg kg BW MSG 2400 mg kg BW and MSG 4800 mg kg BW The result showed an increased percentage of normal neurons on MSG group compared to control group This increment is not significant statiscally on group MSG 1200 mg kg BW and 4800 mg kg BW Nevertheless on group who was given MSG 2400 mg kg BW there was a significant increased of normal neuron percentage p]