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ABSTRAKDaun alpukat (Persea americana Mill.) berkhasiat sebagai antihiperlipidemik. Penelitian bertujuan memperoleh perbandingan optimum adsorben dan ekstrak
kental daun alpukat serta formula sediaan kapsul ekstrak daun alpukat. Ekstrak dibuat dengan cara maserasi menggunakan etanol 70% dan dikeringkan dengan
penambahan aerosil pada berbagai perbandingan (1: 0,025; 1:0,05; 1:0,8; 1:0,11 dan 1:0,2) dan magnesium karbonat pada berbagai perbandingan (1:0,08; 1:0,11;
1:0,15; 1:0,3; 1:0,4; dan 1:0,5). Formulasi kapsul ekstrak daun Tanaman alpukat
menggunakan amilum jagung dan kalsium fosfat dibasa sebagai pengisi. Evaluasi
massa serbuk meliputi uji bulk dan tapped density, laju alir dan sudut istirahat.
Evaluasi kapsul eksrak daun tanaman alpukat dilakukan meliputi uji waktu hancur, uji keragaman bobot. Hasil penelitian menunjukkan perbandingan
optimum aerosil sebagai adsorben adalah 1:0,2 terhadap bobot ekstrak kental sedangkan magnesium karbonat sebagai adsorben adalah 1:0,5 terhadap bobot
ekstrak kental.
ABSTRAKThe Leaf of avocado (Persea americana Mill.) has antihyperlipidaemic properties.
This study was aimed to achieve optimized composition of adsorbent and viscous
avocado leaf extract and to make capsule of avocado leaf extract. Extract was
made by maseration with Ethanol 70% and dried using Aerosil within different
ratio (1: 0,025; 1:0,05; 1:0,8; 1:0,11 and 1:0,2) and Magnesium Carbonate within
different ratio (1:0,08; 1:0,11; 1:0,15; 1:0,3; 1:0,4; and 1:0,5). Formulation of
avocado leaf extract used Corn Starch and Dibasic Calcium Phosphat as filler.
Evaluation of dried extract included bulk and tapped density test, flowability test
and angle of rephose. Evaluation of avocado leaf extract capsule included
desintegration time, uniformity of weight. The study shows optimal ratio of
Aerosil as adsorbent which is 1:0,2 to weight of viscous extract. Then the optimal
ratio using Magnesium carbonate as adsorbent is 1:0,5 to weight of viscous
extract., The Leaf of avocado (Persea americana Mill.) has antihyperlipidaemic properties.
This study was aimed to achieve optimized composition of adsorbent and viscous
avocado leaf extract and to make capsule of avocado leaf extract. Extract was
made by maseration with Ethanol 70% and dried using Aerosil within different
ratio (1: 0,025; 1:0,05; 1:0,8; 1:0,11 and 1:0,2) and Magnesium Carbonate within
different ratio (1:0,08; 1:0,11; 1:0,15; 1:0,3; 1:0,4; and 1:0,5). Formulation of
avocado leaf extract used Corn Starch and Dibasic Calcium Phosphat as filler.
Evaluation of dried extract included bulk and tapped density test, flowability test
and angle of rephose. Evaluation of avocado leaf extract capsule included
desintegration time, uniformity of weight. The study shows optimal ratio of
Aerosil as adsorbent which is 1:0,2 to weight of viscous extract. Then the optimal
ratio using Magnesium carbonate as adsorbent is 1:0,5 to weight of viscous
extract.]