Hiperlipidemia adalah peningkatan salah satu atau lebih dari kolesterol, kolesterol ester, fosfolipid, atau trigliserida. Allium schenoprasum L. merupakan tanaman satu genus dari Allium sativum yang sudah teruji efek hiperlipidemianya. Penelitian ini bertujuan untuk mengetahui efek antihiperlipidemia ekstrak etanol 80% kucai (Allium schoenoprasum L.) pada tikus jantan yang diberi diit tinggi kolesterol dan lemak. Sebanyak 36 tikus putih jantan galur Sparague dawley dibagi secara acak ke dalam 6 kelompok perlakuan, yaitu kelompok normal, induksi, simvastatin, dan 3 kelompok dosis. Semua kelompok diberi diit tinggi kolesterol dan lemak kecuali kelompok normal. Kelompok normal hanya diberikan CMC 0,5%. Setelah 1 jam pemberian diit tinggi kolesterol dan lemak, kelompok induksi, simvastatin, dosis 1, dosis 2, dan dosis 3 secara berturut-turut diberikan larutan CMC 0,5%, simvastatin 1,8 mg/200 g bb, ekstrak kucai 4,79 mg, 9,58 mg, dan 19,16 mg/200 g bb. Setelah 56 hari perlakuan, sampel darah tikus diambil melalui sinus orbital dan dilakukan penetapan kadar kolesterol total, trigliserida, HDL, dan LDL pada plasma darah tikus. Hasil penelitian menunjukkan bahwa ekstrak etanol 80% umbi kucai memiliki efek antihiperlipidemia pada dosis 9,58 mg/200 g bb dilihat dari penurunan kadar kolesterol total, trigliserida, dan LDL dan memberikan hasil berbeda bermakna dibandingkan dengan kelompok induksi (p <0,05).

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Hyperlipidemia is defined as an elevation of one or more of cholesterol, cholesterol esters, phospholipids, or triglycerides. Allium schoenoprasum L. is a plant of the same genus with Allium sativum which had been proven to have effect as antihyperlipidemia. This study aimed to evaluate antihyperlipidemic effects of 80% ethanolic extract of chives (Allium schoenoprasum L.) in male rats induced by high cholesterol and fat diet. Thirty-six male rats of Sprague dawley strain were divided randomly into 6 groups, those were normal group, induction group, simvastatin group, and three dose groups. All groups except the normal group were given high dietary cholesterol and fat. The normal group was given only 0,5 % CMC solution. After one hour of high dietary cholesterol and fat administration, the induction group, simvastatin group, dose I group, dose II group, and dose III group were given 0,5% CMC solution, 1,8 mg/200 g bw simvastatin, 4,79 mg/200 g bw, 9,58 mg/200 g bw, and 19,16 mg/200 g bw chives extract as follows. Blood samples were collected by the orbital sinus after 56 days of treatment to be analysed for total cholesterol, triglycerides, HDL, and LDL. The results showed that 80% ethanolic extract of bulbs chives have antihyperlipidemic effects at dose of 9,58 mg/200 g bw proven by significant (p < 0,05) decreases in total cholesterol, triglycerides, and LDL compared to induction group.