[Karies merupakan penyakit infeksius yang paling sering terjadi pada anak di Indonesia. Oleh karena itu, dibutuhkan solusi yang dapat mengatasi karies, salah satunya dengan aplikasi Silver Diamine Fluoride (SDF). Tujuan: membahas evaluasi aplikasi SDF dalam mengatasi karies anak dan faktor-faktor yang berhubungan dengan persentase karies terhenti setelah aplikasi SDF. Metode: Studi kohort untuk evaluasi dan cross sectional dengan subjek penelitian 115 anak usia 3-5 tahun yang memiliki karies dentin aktif. Kuesioner diisi oleh orangtua untuk mengetahui faktor risiko karies. Hasil: Evaluasi pada 3 dan 10 bulan memperlihatkan permukaan karies aktif berpeluang terhenti 9.9 dan 6.8 kali setelah diaplikasi SDF, dibandingkan dengan yang tidak diaplikasi. Kesimpulan: SDF efektif menghentikan karies aktif anak serta meringankan rasa sakit yang diderita anak akibat karies sehingga berpotensi meningkatkan quality of life anak.;Dental caries is one of the most prevalent infectious disease in children in Indonesia. Therefore, solution to overcome caries is needed. Objective: evaluate Silver Diamine Fluoride (SDF) applications to overcome caries in children and factors related to the percentage of arrested caries after SDF application. Method: Cohort study to evaluation and cross sectional with 115 children aged 3-5 years old who had active dentin caries were the subjects. Caries risk factors questionnaires filled by parents? subject. Results: Active caries which were applied SDF had odd ratios 9.9 and 6.8 times being arrested after 3 and 10 months, respectively, compared with those not applied. Conclusion: SDF is effective to arrest caries and decrease toothache suffered by children, thus potentially increase the quality of life of children., Dental caries is one of the most prevalent infectious disease in children in Indonesia. Therefore, solution to overcome caries is needed. Objective: evaluate Silver Diamine Fluoride (SDF) applications to overcome caries in children and factors related to the percentage of arrested caries after SDF application. Method: Cohort study to evaluation and cross sectional with 115 children aged 3-5 years old who had active dentin caries were the subjects. Caries risk factors questionnaires filled by parents’ subject. Results: Active caries which were applied SDF had odd ratios 9.9 and 6.8 times being arrested after 3 and 10 months, respectively, compared with those not applied. Conclusion: SDF is effective to arrest caries and decrease toothache suffered by children, thus potentially increase the quality of life of children.]