[ABSTRAK
Morbiditas dan mortalitas apendisitis akut disebabkan karena perkembangan apendisitis akutmenjadi perforasi apendiks. Hal-hal yang menyebabkan kerentanan apendiks belum banyakditeliti dan belum diketahui sebab pastinya. Tujuan dari penelitian ini adalah untukmengetahui faktor-faktor apa saja yang dapat memprediksi terjadinya perforasi apendiks.Penelitian menggunakan desain kasus kontrol menggunakan data sekunder berupa rekammedis penderita apendisitis akut dewasa tahun 2013-2014 dengan jumlah kasus (perforasiapendiks) 36 dan kontrol (non perforasi) 93. Analisis data yang dilakukan meliputi deskriptif,chi square, receiver operating characteristic, dan regresi logistik multivariat. Dua faktorprediksi yang bermakna sebagai faktor prediksi perforasi apendiks dalam analisis regresilogistik multivariat adalah suhu badan diatas 37,50C dengan odds ratio (OR) 7,54 (95% CI2,01; 28,33), jumlah leukosit diatas 11.500/mm3 dengan OR 12,12 (95% CI 4,03; 36,48)Perlu validasi pemeriksaan suhu badan di RS, penelitian lebih lanjut untuk mencari faktorprediksi lainnya, persiapan operasi segera untuk pencegahan komplikasi perforasi apendiks,dan pemberian informasi ke masyarakat bahwa sakit perut dapat bersifat gawat darurat.

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ABSTRACT
Appendix perforation is the causation for acute appendicitis morbidity and mortality . Factorsthat may cause appendix vulnerability has not been extensively studied before and the maincause is still yet unknown. The goal of this study is to analyze what factors that could be usedto predict appendix perforation. This study is a case control study using 2013-2014 medicalrecords as data. Case group pooled from 36 perforated appendix adult (above 15 years old)patients, while control group pooled from 93 non perforated appendix adult patients. Dataanalysis conducted are descriptive, chi square, receiver operating characteristic, andmultivariate logistic regression. There are two prediction factors which significantlyassociated with perforated appendix. Those are body temperature above 37,50C with oddsratio (OR) 7,54 (95% CI 2,01; 28,33), and leucocytes count above 11.500/mm3 with OR12,12 (95% CI 4,03; 36,48). Further studies and body temperature validation on each hospitalare needed to find other prediction factors, preparing pre operative equipment for immediatedefinite measure like surgery, to prevent the complication of perforated appendix, andeducation to people that abdominal pain is not always causing by gastric problem and itmight be a case of emergency.;Appendix perforation is the causation for acute appendicitis morbidity and mortality . Factorsthat may cause appendix vulnerability has not been extensively studied before and the maincause is still yet unknown. The goal of this study is to analyze what factors that could be usedto predict appendix perforation. This study is a case control study using 2013-2014 medicalrecords as data. Case group pooled from 36 perforated appendix adult (above 15 years old)patients, while control group pooled from 93 non perforated appendix adult patients. Dataanalysis conducted are descriptive, chi square, receiver operating characteristic, andmultivariate logistic regression. There are two prediction factors which significantlyassociated with perforated appendix. Those are body temperature above 37,50C with oddsratio (OR) 7,54 (95% CI 2,01; 28,33), and leucocytes count above 11.500/mm3 with OR12,12 (95% CI 4,03; 36,48). Further studies and body temperature validation on each hospitalare needed to find other prediction factors, preparing pre operative equipment for immediatedefinite measure like surgery, to prevent the complication of perforated appendix, andeducation to people that abdominal pain is not always causing by gastric problem and itmight be a case of emergency., Appendix perforation is the causation for acute appendicitis morbidity and mortality . Factorsthat may cause appendix vulnerability has not been extensively studied before and the maincause is still yet unknown. The goal of this study is to analyze what factors that could be usedto predict appendix perforation. This study is a case control study using 2013-2014 medicalrecords as data. Case group pooled from 36 perforated appendix adult (above 15 years old)patients, while control group pooled from 93 non perforated appendix adult patients. Dataanalysis conducted are descriptive, chi square, receiver operating characteristic, andmultivariate logistic regression. There are two prediction factors which significantlyassociated with perforated appendix. Those are body temperature above 37,50C with oddsratio (OR) 7,54 (95% CI 2,01; 28,33), and leucocytes count above 11.500/mm3 with OR12,12 (95% CI 4,03; 36,48). Further studies and body temperature validation on each hospitalare needed to find other prediction factors, preparing pre operative equipment for immediatedefinite measure like surgery, to prevent the complication of perforated appendix, andeducation to people that abdominal pain is not always causing by gastric problem and itmight be a case of emergency.]