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ABSTRAKElectro Capacitive Cancer Therapy (ECCT) telah dikembangkan untuk terapi
kanker payudara dengan medan elektrostatik dari gelombang sinyal yang berasal
dari elektroda kapasitif. Tujuan dari penelitian ini adalah untuk mengetahui
pengaruh perubahan nilai beda potensial dan output gelombang sinyal yang
dihsilkan ECCT terhadap pertumbuhan sel kanker dan cidera sel yang
menyebabkan kematian sel. Dilakukan eksperimen in vitro menggunakan cell line
MCF-7 (kanker payudara manusia) selama 24, 48 dan 72 jam perlakuan. Kemudian
dilakukan perhitungan jumlah sel dengan hemocytometer dan pengukuran
kapasitansi sel sebelum dan sesudah diberikan perlakuan. Hasil eksperimen
menunjukkan bahwa ECCT standar sinyal kotak 18 Volt dan ECCT non standar
sinyal kotak 31.2 Volt dapat menghambat pertumbuhan sel dan hasil morfologi sel
tampak cidera yang mengindikasi adanya kematian, sedangkan ECCT standar
sinyal sinusoidal 18 Volt mampu menginduksi pertumbuhan sel sehingga
jumlahnya semakin banyak jika dilihat dari koefisien pertumbuhan yang tinggi.
Pengukuran nilai kapasitansi sel menunjukkan korelasi antara banyaknya jumlah
sel dengan besarnya nilai kapasitansi yang terukur. Peningkatan nilai kapasitansi
dapat menunjukkan penambahan aktifitas kelistrikan sel dan tingkat keganasan
dari sel kanker.
ABSTRACTElectro Capacitive Cancer Therapy (ECCT) has been developed for breast cancer
therapy that generated electrostatic field from electrical wave in capacitive
electrode. The purpose of this research is to find out the effect of potential
difference and signal wave output ECCT to cancer cell growth and cell injury that
leads to lethal cell. In this study, in vitro experiment use MCF-7 cell line (human
breast cancer) during 24, 48 and 72 hours treatment and than measured the number
of cell with hemocytometer and value of capacitance after and before treatment.
The results showed that potential ECCT square signal wave standard 18 Volt and
square signal non-standard 31.2 Volt can inhibit cancer cell growth and cell
morphology results seem to indicate the existence of injury deaths. While, from
growth coefficient, ECCT sinusoidal signal wave standard 18 Volt can increase of
cancer cell growth. Measurement of cell capacitance values showed correlation
between the number of cells with the value of the measured capacitance. Increase
of capacitance indicate of high activity of cancer cell and showed the malignancy
of cancer cell levels.;Electro Capacitive Cancer Therapy (ECCT) has been developed for breast cancer
therapy that generated electrostatic field from electrical wave in capacitive
electrode. The purpose of this research is to find out the effect of potential
difference and signal wave output ECCT to cancer cell growth and cell injury that
leads to lethal cell. In this study, in vitro experiment use MCF-7 cell line (human
breast cancer) during 24, 48 and 72 hours treatment and than measured the number
of cell with hemocytometer and value of capacitance after and before treatment.
The results showed that potential ECCT square signal wave standard 18 Volt and
square signal non-standard 31.2 Volt can inhibit cancer cell growth and cell
morphology results seem to indicate the existence of injury deaths. While, from
growth coefficient, ECCT sinusoidal signal wave standard 18 Volt can increase of
cancer cell growth. Measurement of cell capacitance values showed correlation
between the number of cells with the value of the measured capacitance. Increase
of capacitance indicate of high activity of cancer cell and showed the malignancy
of cancer cell levels., Electro Capacitive Cancer Therapy (ECCT) has been developed for breast cancer
therapy that generated electrostatic field from electrical wave in capacitive
electrode. The purpose of this research is to find out the effect of potential
difference and signal wave output ECCT to cancer cell growth and cell injury that
leads to lethal cell. In this study, in vitro experiment use MCF-7 cell line (human
breast cancer) during 24, 48 and 72 hours treatment and than measured the number
of cell with hemocytometer and value of capacitance after and before treatment.
The results showed that potential ECCT square signal wave standard 18 Volt and
square signal non-standard 31.2 Volt can inhibit cancer cell growth and cell
morphology results seem to indicate the existence of injury deaths. While, from
growth coefficient, ECCT sinusoidal signal wave standard 18 Volt can increase of
cancer cell growth. Measurement of cell capacitance values showed correlation
between the number of cells with the value of the measured capacitance. Increase
of capacitance indicate of high activity of cancer cell and showed the malignancy
of cancer cell levels.]