[
ABSTRAKTerapi Paliatif bertujuan untuk meningkatkan kualitas hidup dan mengurangi
gejala, namun menambah kompleksitas terapi pasien. Penelitian ini bertujuan
untuk menganalisis profil pengobatan dan prevalensi DRPs yang terjadi pada
pasien yang menjalani terapi paliatif di RSK ?Dharmais?. Penelitian ini adalah
penelitian cross sectional. Data pada penelitian diambil secara prospektif dari data
medis pasien bulan maret sampai juni 2011. Karakteristik pasien, 33 orang
(68,8%) perempuan, 15 orang (31,3%) laki-laki, dan kasus kanker padat terbesar
adalah kasus kanker payudara sebanyak 15 orang (33,3%). Berdasarkan profil
pengobatan, 64,6% hanya menjalani satu kali terapi paliatif. Reaksi obat yang
tidak diinginkan (ROTD) manifestasi dialami olah 70,1% subyek uji dan 66,2%
mengalami ROTD potensial. Lima koma tujuh persen (5,7%) mengalami interaksi
dengan signifikansi moderate dan 15,0% terjadi karena pemakaian morphine, dan
amitriptyline. Peningkatan risiko kejadian ROTD dipengaruhi oleh (1) usia,
bertambahnya usia tidak selalu menyebabkan peningkatan ROTD manifestasi; (2)
jenis kelamin, laki-laki akan lebih berisiko mengalami peningkatan ROTD
manifestasi; (3) riwayat rejimen kemoterapi kuratif, meningkatkan risiko ROTD
manifestasi; (4) penyakit penyerta, meningkatkan risiko ROTD manifestasi dan
potensial; (5) jumlah obat; penggunaan > 5 jenis obat dapat meningkatkan risiko
ROTD manifestasi dan ROTD potensial. Risiko kejadian interaksi obat
dipengaruhi oleh faktor adanya penyakit penyerta dan penggunaan > 5 jenis obat.
ABSTRACTThe goal of palliative care is to increase the quality of life and to reduce the
symptomps, but its often increace the complexity of patient?s therapy. The aim of
these research is to analyst the patient?s therapy profile and the prevalence of
DRPs of patient undergoing the palliative care at ?Dharmais? Hospital National
Cancer Center. This reasearch is a cross sectional study. The data of the research
is prospectively taken from the patients? medical records start from march to june
2011. The patient characteristic who followed the reasearch are 33 patients
(68.8%) women, 15 patient (31.3%) men, and the most solid cancer case are
breast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only had
once palliative care. Manifest adverse reaction happen in 70.1% patient of
subject and 66.2% subjects get potential adverse reaction. Five point seven
percent (5.7%) of drug interaction had moderate signification, 15.0% caused by
the morphine, and amitriptyline use. The risk of incident adverse reactions
influenced by (1) age, increasing the age not always increase the risk of having
the manifest adverse reaction, (2) sex, men will have higher risk of manifest
adverse reaction, (3) history of curative chemotherapy regimen, increase the risk
of manifest adverse reaction, (4) comorbidities will increase the risk of manifest
and potential adverse reaction, (5) the number of drug use, using more than 5
drugs ( > 5 drugs) will increase the risk of manifest and potential adverse
reaction. The risk of drug interaction will increase because of the comorbidities
and the number of drugs using ( > 5 drugs).;The goal of palliative care is to increase the quality of life and to reduce the
symptomps, but its often increace the complexity of patient’s therapy. The aim of
these research is to analyst the patient’s therapy profile and the prevalence of
DRPs of patient undergoing the palliative care at “Dharmais” Hospital National
Cancer Center. This reasearch is a cross sectional study. The data of the research
is prospectively taken from the patients’ medical records start from march to june
2011. The patient characteristic who followed the reasearch are 33 patients
(68.8%) women, 15 patient (31.3%) men, and the most solid cancer case are
breast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only had
once palliative care. Manifest adverse reaction happen in 70.1% patient of
subject and 66.2% subjects get potential adverse reaction. Five point seven
percent (5.7%) of drug interaction had moderate signification, 15.0% caused by
the morphine, and amitriptyline use. The risk of incident adverse reactions
influenced by (1) age, increasing the age not always increase the risk of having
the manifest adverse reaction, (2) sex, men will have higher risk of manifest
adverse reaction, (3) history of curative chemotherapy regimen, increase the risk
of manifest adverse reaction, (4) comorbidities will increase the risk of manifest
and potential adverse reaction, (5) the number of drug use, using more than 5
drugs ( > 5 drugs) will increase the risk of manifest and potential adverse
reaction. The risk of drug interaction will increase because of the comorbidities
and the number of drugs using ( > 5 drugs)., The goal of palliative care is to increase the quality of life and to reduce the
symptomps, but its often increace the complexity of patient’s therapy. The aim of
these research is to analyst the patient’s therapy profile and the prevalence of
DRPs of patient undergoing the palliative care at “Dharmais” Hospital National
Cancer Center. This reasearch is a cross sectional study. The data of the research
is prospectively taken from the patients’ medical records start from march to june
2011. The patient characteristic who followed the reasearch are 33 patients
(68.8%) women, 15 patient (31.3%) men, and the most solid cancer case are
breast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only had
once palliative care. Manifest adverse reaction happen in 70.1% patient of
subject and 66.2% subjects get potential adverse reaction. Five point seven
percent (5.7%) of drug interaction had moderate signification, 15.0% caused by
the morphine, and amitriptyline use. The risk of incident adverse reactions
influenced by (1) age, increasing the age not always increase the risk of having
the manifest adverse reaction, (2) sex, men will have higher risk of manifest
adverse reaction, (3) history of curative chemotherapy regimen, increase the risk
of manifest adverse reaction, (4) comorbidities will increase the risk of manifest
and potential adverse reaction, (5) the number of drug use, using more than 5
drugs ( > 5 drugs) will increase the risk of manifest and potential adverse
reaction. The risk of drug interaction will increase because of the comorbidities
and the number of drugs using ( > 5 drugs).]
T42521-Ema Nillafita Putri Kusuma.pdf :: Unduh