[ Latar Belakang Tindakan peritomi konjungtiva meningkatkan penanda inflamasi
pada permukaan okular dan menyebabkan penurunan densitas sel goblet yang
berimplikasi pada ketidakstabilan lapisan air mata. Pemberian HP-guar diharapkan
mampu memperbaiki keadaan permukaan okular pasca peritomi konjungtiva 360°
dibandingkan kontrol.
Tujuan Untuk menilai efektivitas artificial tears HP-guar dalam melindungi
permukaan okular pasien pasca peritomi konjungtiva 360°.
Desain Penelitian prospektif, uji klinis open label
Hasil Terdapat 23 subjek yang berpartisipasi dalam penelitian ini. Kelompok HP-guar
menunjukkan hasil yang lebih baik dibandingkan dengan kelompok kontrol secara
signifikan dalam hal TFBUT (9,43+2,20 vs 5,95+1,93, p=0,001), densitas sel goblet
(68,73 ±97,49 vs 10,00 ± 22,09,p =0,012), skor epitel (1,73±1.00 vs 4,55±1.57,
p=0.000). Tidak terdapat perbedaan bermakna antara kedua kelompok dalam hal skor
lissamine green (1,33±1,55 vs 2,18±1,72, p=0,146) dan IL-6 air mata (60,32 ±17,86
vs 57,44 ±24,67, p=0,782)
Kesimpulan Pemberian HP-guar lebih memperbaiki nilai TFBUT, densitas sel goblet
dan epitel konjungtiva dibandingkan kontrol. HP-guar tidak berpengaruh terhadap
skor lissamine green dan kadar IL-6 air mata., Background Conjunctival peritomy, a step commonly done in ocular surgery,
increases ocular surface inflammation and decreases goblet cell density (GCD) that
could lead to tear film instability. Hydroxypropyl-guar (HP-guar) is expected to
improve ocular surface related to conjunctival peritomy
Purpose To evaluate HP-guar effectiveness in protecting ocular surface after
conjunctival peritomy
Methods Randomized controlled trial, open label study, on subjects underwent scleral
buckling surgery
Result Twenty-three participants were involved in this study. The HP-guar group
showed statistically better results compared to the control group regarding Tear-film
break-up time (TFBUT) (9,43±2,20 vs 5,95±1,93, p=0.001), GCD (68,73 ±97,49 vs
10,00 ± 22,09,p =0.012), and epithelial score (1.73±1.00 vs 4.55±1.57, p=0.000). No
statistical differences were found between groups in lissamine green score (1.33±1.55
vs 2.18±1.72, p=0.146) and IL-6 tear fluid level (60.32 ±17.86 vs 57.44 ±24.67,
p=0.782)
Conclusion The addition of HP-Guar to regular treatment after conjunctival peritomy
increases TFBUT, goblet cell density, and improves conjunctival epithelial cells. HPguar
has no effect on ocular surface inflammation.]