[Latar belakang. Timbulnya stasis darah dan pembesaran atrium kiri menyebabkan
peningkatan angka kejadian trombus di atrium kiri dan apendiks atrium kiri (Left Atrial
Appendage-LAA) pada SM. Diameter atrium kiri yang membesar disebutkan sebagai faktor
terjadinya pembentukan LASEC dan meningkatkan angka kejadian tromboemboli. Selain itu
adanya stasis darah yang dibuktikan dengan penurunan ejeksi fraksi LAA dan kecepatan
aliran darah LAA dapat mencetuskan timbulnya trombus. Perubahan moluker adhesi sICAM-
1 dan sVCAM-1 berhubungan dengan kejadian tromboemboli. Tetapi apakah terdapat
hubungan antara peran hemodinamik, terutama terhadap diameter, fraksi ejeksi dan kecepatan
aliran darah pada LAA dengan kadar molekul adhesi seperti sICAM-1 dan sVCAM-1 belum
terjawab.
Metode. Pasien SM derajat sedang-berat (tanpa adanya regurgitasi mitral signifikan) yang
menjalani pemeriksan ekokardiografi transesofageal diikutsertakan secara konsekutif sejak
Januari-April 2014. Penilaian fungsi apendiks atrium kiri dilakukan dengan pemeriksaan
transesofageal ekokardiografi. Kadar sICAM-1 dan sVCAM-1 dari vena perifer diukur
dengan teknik enzyme-linked immunosorbent assay.
Hasil. Sebanyak 26 subyek penelitian dengan rerata usia 38,92±11,93 tahun, 65,3% berjenis
kelamin perempuan, dan 46,1% memiliki irama fibrilasi atrium. Dengan sampel tersebut,
didapatkan tidak ada hubungan antara komponen fungsi apendiks atrium kiri, baik diameter,
ejeksi fraksi, dan kecepatan aliran darah LAA dengan kadar sICAM-1. Tidak terdapat
hubungan antara fungsi LAA pada variabel diameter dengan kadar sVCAM-1. Terdapat
hubungan terbalik antara ejeksi fraksi LAA dengan kadar sVCAM-1 (-0,21, p=0.038, 95%KI
-0,41- -0,01) dan hubungan terbalik antara kecepatan aliran darah LAA dengan kadar
sVCAM-1 (-0,29, p=0,048, 95%KI -0,59- -0,003).
Kesimpulan. Semakin rendah ejeksi fraksi dan kecepatan aliran darah LAA maka semakin
tinggi kadar sVCAM-1.
Background: Blood stasis and left atrial enlargement increase the incidence of thrombus inthe left atrium and left atrial appendage (LAA). Enlargement of left atrial diameter is a factorfor LASEC formation and increase the incidence of thromboembolism. Blood stasis whichevidenced by a decrease in ejection fraction and LAA blood flow velocity can trigger thepresence of thrombus. Changes in soluble adhesion molecules sICAM-1 and sVCAM-1associated with thromboembolic events. But relationship between the role of hemodynamics,especially the ejection fraction and blood flow velocity in the LAA with the levels ofadhesion molecules such as sICAM-1 and sVCAM-1 is not well understood.Methods: Patient with moderate-severe Mitral Stenosis (in the absence of significant mitralregurgitation) underwent transesophageal echocardiography from January to April 2014.Levels of sICAM-1 and sVCAM-1 from peripheral vein were measured by enzyme-linkedimmunosorbent technique assay.Results: A total of 26 subjects with a mean age of 38.92 ± 11.93 years, 65.3% female, and46.1% had atrial fibrillation. We found no association between components of left atrialappendage function: diameter, ejection fraction and blood flow velocity of LAA withsICAM-1 levels. There was no relationship between the LAA function in the variablediameter of LAA with sVCAM-1 levels. There is an inverse relationship between ejectionfraction of LAA and levels of sVCAM-1 (-0.21, p = 0.038, 95% KI -0,41- -0,01) and aninverse association between LAA blood flow velocity and levels of sVCAM-1 (-0 , 29, p =0.048, 95% KI -0.59 - 0.003).Conclusion: Low ejection fraction of LAA is associated with higher the levels of sVCAM-1.Low LAA blood flow velocity is associated with higher the levels of sVCAM-1.;Background: Blood stasis and left atrial enlargement increase the incidence of thrombus inthe left atrium and left atrial appendage (LAA). Enlargement of left atrial diameter is a factorfor LASEC formation and increase the incidence of thromboembolism. Blood stasis whichevidenced by a decrease in ejection fraction and LAA blood flow velocity can trigger thepresence of thrombus. Changes in soluble adhesion molecules sICAM-1 and sVCAM-1associated with thromboembolic events. But relationship between the role of hemodynamics,especially the ejection fraction and blood flow velocity in the LAA with the levels ofadhesion molecules such as sICAM-1 and sVCAM-1 is not well understood.Methods: Patient with moderate-severe Mitral Stenosis (in the absence of significant mitralregurgitation) underwent transesophageal echocardiography from January to April 2014.Levels of sICAM-1 and sVCAM-1 from peripheral vein were measured by enzyme-linkedimmunosorbent technique assay.Results: A total of 26 subjects with a mean age of 38.92 ± 11.93 years, 65.3% female, and46.1% had atrial fibrillation. We found no association between components of left atrialappendage function: diameter, ejection fraction and blood flow velocity of LAA withsICAM-1 levels. There was no relationship between the LAA function in the variablediameter of LAA with sVCAM-1 levels. There is an inverse relationship between ejectionfraction of LAA and levels of sVCAM-1 (-0.21, p = 0.038, 95% KI -0,41- -0,01) and aninverse association between LAA blood flow velocity and levels of sVCAM-1 (-0 , 29, p =0.048, 95% KI -0.59 - 0.003).Conclusion: Low ejection fraction of LAA is associated with higher the levels of sVCAM-1.Low LAA blood flow velocity is associated with higher the levels of sVCAM-1., Background: Blood stasis and left atrial enlargement increase the incidence of thrombus inthe left atrium and left atrial appendage (LAA). Enlargement of left atrial diameter is a factorfor LASEC formation and increase the incidence of thromboembolism. Blood stasis whichevidenced by a decrease in ejection fraction and LAA blood flow velocity can trigger thepresence of thrombus. Changes in soluble adhesion molecules sICAM-1 and sVCAM-1associated with thromboembolic events. But relationship between the role of hemodynamics,especially the ejection fraction and blood flow velocity in the LAA with the levels ofadhesion molecules such as sICAM-1 and sVCAM-1 is not well understood.Methods: Patient with moderate-severe Mitral Stenosis (in the absence of significant mitralregurgitation) underwent transesophageal echocardiography from January to April 2014.Levels of sICAM-1 and sVCAM-1 from peripheral vein were measured by enzyme-linkedimmunosorbent technique assay.Results: A total of 26 subjects with a mean age of 38.92 ± 11.93 years, 65.3% female, and46.1% had atrial fibrillation. We found no association between components of left atrialappendage function: diameter, ejection fraction and blood flow velocity of LAA withsICAM-1 levels. There was no relationship between the LAA function in the variablediameter of LAA with sVCAM-1 levels. There is an inverse relationship between ejectionfraction of LAA and levels of sVCAM-1 (-0.21, p = 0.038, 95% KI -0,41- -0,01) and aninverse association between LAA blood flow velocity and levels of sVCAM-1 (-0 , 29, p =0.048, 95% KI -0.59 - 0.003).Conclusion: Low ejection fraction of LAA is associated with higher the levels of sVCAM-1.Low LAA blood flow velocity is associated with higher the levels of sVCAM-1.]