[Pendahuluan: Kanker payudara lokal lanjut merupakan skenario klinis yang amat
sering dijumpai di negara berkembang, dimana rekurensi masih menjadi
permasalahan. Mastektomi merupakan salah satu terapi utama. Usia, stadium
klinis, keterlibatan kelenjar getah bening, tipe histopatologis, grade histopatologis,
subtipe tumor merupakan faktor-faktor klinikohistopatologis yang mempengaruhi
rekurensi. Tujuan penelitian ini adalah untuk mengetahui pengaruh faktor-faktor
tersebut terhadap rekurensi kanker payudara lokal lanjut pasca mastektomi.
Metode: Desain penelitian bersifat analitik potong lintang. Pengumpulan data
dilakukan pada semua pasien kanker payudara lokal lanjut yang telah dilakukan
mastektomi serta terapi definitif sesuai stadium tumor dan terdapat disease free
interval serta dapat diikuti minimal 24 bulan pada periode Januari 2011 –
Desember 2012 di RS Dr.Cipto Mangunkusumo.
Hasil: Didapatkan 39 pasien dengan kanker payudara lokal lanjut yang telah
dilakukan mastektomi serta terapi definitif dan terdapat disease free interval
dengan median follow up 30 bulan. Jumlah rekurensi adalah 7,6%. Pada analisis
bivariat ditemukan hubungan bermakna antara jenis histopatologi (p 0,008) dan
keterlibatan kelenjar getah bening (p 0,026) dengan rekurensi. Pada analisis
multivariat didapati faktor yang paling berpengaruh terhadap rekurensi adalah
keterlibatan kelenjar getah bening (p 0,002).
Konklusi: Faktor yang paling berpengaruh terhadap terjadinya rekurensi kanker
payudara lokal lanjut pasca mastektomi adalah kelenjar getah bening positif tumor
dengan jumlah lebih dari tiga.;Introduction: Locally advanced breast cancer is clinical scenario that is very
common in developing countries where recurrence is still a problem. Mastectomy
is one of the primary teraphy. Age, clinical stage, lymph nodes involvement,
histopathlogic type, histopatologic grades, tumor subtypes are
clinicohystopatoligic factors affecting recurrence. The purpose of this study was
to determine the influence of these factors on the recurrence of locally advanced
breast cancer after mastectomy.
Methodology: The study design was analytical cross-sectional. Data collection
was performed in all patients with locally advanced breast cancer who had
performed mastectomy and appropriate definitive therapy according to tumor
stage, had disease free interval and can be followed at least 24 month in the period
January 2011 – December 2012 at the Hospital Dr. Cipto Mangunkusumo.
Result: There were 39 patient with locally advanced breast cancer patient who had
performed mastectomy as well as definitive therapy, had disease free interval with
a median follow-up interval of 30 months. The number of recurrences was 7,6%.
In the bivariate analysis found a significant relationship between the
hystopathology type (p 0,008), lymph node involvement (p 0,026) with
recurrence. In multivariate analysis found that the most influential factor to
reccurrence was lymph node involvement (p 0,002).
Conclusion: The most influential factor on the occurrence of locally advanced
breast cancer recurrence after mastectomy is tumor positive lymph nodes in an
amount greater than three.;Introduction: Locally advanced breast cancer is clinical scenario that is very
common in developing countries where recurrence is still a problem. Mastectomy
is one of the primary teraphy. Age, clinical stage, lymph nodes involvement,
histopathlogic type, histopatologic grades, tumor subtypes are
clinicohystopatoligic factors affecting recurrence. The purpose of this study was
to determine the influence of these factors on the recurrence of locally advanced
breast cancer after mastectomy.
Methodology: The study design was analytical cross-sectional. Data collection
was performed in all patients with locally advanced breast cancer who had
performed mastectomy and appropriate definitive therapy according to tumor
stage, had disease free interval and can be followed at least 24 month in the period
January 2011 – December 2012 at the Hospital Dr. Cipto Mangunkusumo.
Result: There were 39 patient with locally advanced breast cancer patient who had
performed mastectomy as well as definitive therapy, had disease free interval with
a median follow-up interval of 30 months. The number of recurrences was 7,6%.
In the bivariate analysis found a significant relationship between the
hystopathology type (p 0,008), lymph node involvement (p 0,026) with
recurrence. In multivariate analysis found that the most influential factor to
reccurrence was lymph node involvement (p 0,002).
Conclusion: The most influential factor on the occurrence of locally advanced
breast cancer recurrence after mastectomy is tumor positive lymph nodes in an
amount greater than three., Introduction: Locally advanced breast cancer is clinical scenario that is very
common in developing countries where recurrence is still a problem. Mastectomy
is one of the primary teraphy. Age, clinical stage, lymph nodes involvement,
histopathlogic type, histopatologic grades, tumor subtypes are
clinicohystopatoligic factors affecting recurrence. The purpose of this study was
to determine the influence of these factors on the recurrence of locally advanced
breast cancer after mastectomy.
Methodology: The study design was analytical cross-sectional. Data collection
was performed in all patients with locally advanced breast cancer who had
performed mastectomy and appropriate definitive therapy according to tumor
stage, had disease free interval and can be followed at least 24 month in the period
January 2011 – December 2012 at the Hospital Dr. Cipto Mangunkusumo.
Result: There were 39 patient with locally advanced breast cancer patient who had
performed mastectomy as well as definitive therapy, had disease free interval with
a median follow-up interval of 30 months. The number of recurrences was 7,6%.
In the bivariate analysis found a significant relationship between the
hystopathology type (p 0,008), lymph node involvement (p 0,026) with
recurrence. In multivariate analysis found that the most influential factor to
reccurrence was lymph node involvement (p 0,002).
Conclusion: The most influential factor on the occurrence of locally advanced
breast cancer recurrence after mastectomy is tumor positive lymph nodes in an
amount greater than three.]
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