Penelitian ini bertujuan untuk menganalisa pengaruh Return on Equity, Earning Per Share, Current Ratio, Quick Ratio, Current Earning, dan Growth Opportunity Terhadap Dividend Payout Ratio Perusahaan Manufaktur yang terdaftar pada Bursa Efek Indonesia pada periode 2010-2013. Variabel-variabel yang digunakan adalah ROE (Return on Equity), EPS (Earning Per Share), CR (Current Ratio), CE (Current Earning), QR (Quick Ratio), dan GO (Growth Opportunity) sebagai variabel bebas, serta DPO (Dividend Payout Ratio) sebagai variabel terikat. Sampel penelitian terdiri dari 28 perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2010 hingga 2013. Model penelitian yang digunakan adalah Fixed Effect Model. Hasil pengujian data panel menunjukkan bahwa CR, QR, CE, dan GO memiliki pengaruh positif dan signifikan terhadap DPO, sementara ROE dan EPS memiliki pengaruh negatif dan signifikan terhadap DPO.This study aim to analyze Return on Equity, Earning Per Share, Current Ratio, Quick Ratio, Current Earning, and Growth Opportunity Effect On Dividend Payout Ratio in Manufacturing Company Listed in Indonesia Stock Exchange Periode 2010-2013. Variables used are ROE (Return on Equity), EPS (Earning Per Share), CR (Current Ratio), QR (Quick Ratio), CE (Current Earning), and GO (Growth Opportunity) as independent variables, and DPO (Dividend Payout Ratio) as dependent variable. Samples used in this study consist of 28 Manufacturing Company listed in Indonesia Stock Exchange period 2010 to 2013. Research model being used in this study is Fixed Effect Model. The result of this study shows that CR, QR, CE, and GO had significant and positive effect on DPO, meanwhile ROE and EPS had significant and negative effect on DPO.