[Latar Belakang: Hormon kortisol dalam cairan krevikular gingiva belum banyak diteliti. Tujuan: Menganalisis hubungan stres akademik terhadap status penyakit periodontal melalui kadar kortisol pada mahasiswa program spesialis FKG UI. Material dan metode: Pemeriksaan Graduate Dental Environtmental Stress (GDES), indeks periodontal (indeks periodontal modifikasi Russel), dan kadar kortisol dengan ELISA assay terhadap 38 subjek. Hasil : Tidak terdapat hubungan antara stres akademik dengan kadar kortisol (p=0,431), stres akademik dengan status penyakit periodontal (p=0,727), dan kadar kortisol dengan status penyakit periodontal mahasiswa spesialis FKG UI (p=0,347), Kesimpulan: Tidak ada hubungan antara stres akademik dengan status penyakit periodontal melalui kadar kortisol., Background : Relationship between stress and periodontitis with cortisol hormone in crevicular gingival fluid have not been studied. Objective : Analyzed relationship between academical stress spesialist students to periodontal status in relation to level of cortisol hormone in gingival crevicular fluid. Material and Methods : 38 subjects examined stress by Graduate Dental Environment Stress; periodontal condition by modified Russel periodontal index, levels of hormone cortisol by ELISA. Result : Relationship between stress and periodontitis (p=0,727), stress and cortisol hormone (p=0,431), cortisol hormone and periodontitis (p=0,347) were not significant. Conclution : No relationship between stress, periodontitis, and level of cortisol hormone.]