Background: West Manggarai district in period January until 2012. infant mortality rate were 34 cases, stillbirths were 33 cases and maternal mortality rate was 9 cases. Methods: This research is qualitative study using Focus Group Discussion (FGD desain, cooperation with head of publick helth center, midwife, nutrition program manager and publick health at health department. Results: Maternal and infant mortality in Labuan Bajo publict healh center caused by maternal nutrional deficiency, infectious diseases such as malaria and typhoid fever, mother less attentin to the baby when the baby's ill and difficult access to health services. the problem solution is pregnant womanshould be regulary having antenathal care, using of mosquito nets. need to be provided cheaper sea transport.Causes of malnutrition and undernourishment is knowledge, parenting skill and infectious diseases such as diarrhea and malaria. To overcome this problem midwife should be proactive giving counseling to families with manutrition children under five. Maternal and infact mortality in `winekang publick health center caused by not availability of hospital at district, pregnant woment still seeking treatment to traditional healers, the implementtation of goverment regulation are less strict and families often late in taking decision to be referred. the solution is health officers must a;ways giving couseling to pregnant woman and cross-sector approach to monitoring. Whereas the main cause nutrional problems is parenting behavior, infectious diseases, and not enaought health food. Conclusion: maternal and infact mortality caused by difficult access to health service, there are pregnant womens who go to traditional healers, not available of hospitals in thr district, also infectious diseases like malaria and diarrhea. the solution is the midwife must active involving the village and subdistrict heads in minitoring pregnant womant, need to provide a boat and build district hospital.