Background: Jamu has be en a long history as an ancient heritage and indigenous wisdom for maintaining and restoring health of Indonesian people. However, as traditional medicine, jamu stilllacks of scientific evidence in terms of efficacy and safety On the other hand, there is a great demand to use jamu in medical services, including the direction of Indonesian President to raise jamu as a therapeutic modality of health care. Methods: To solve this problem, the Indonesian Ministry of Health has established the Programme of Jamu Scientification, trying to provide scientific evidence through research and development, regarding the efficacy and safety of jamu. Jamu Scientification can be seen as a breakthrough effort to accelerate jamu research in down stream side. Jamu, as part of traditional medicine, use naturopathic approach, focusing on healing instead of removing disease, as contrasted to allopathic medicine. Coventional medicine uses alloptahic approach, implementing more radical treatment, i.e. modern drugs and surgeries. Results: Jamu Scientification is trying to synthesize naturopathic approach and allopathic approach to be integrative medicine. Consequently, the evaluation of clinical outome for Jamu Scientification is using holistic approach, as the phylosophy of integrative medicine. The clinical outcome is not only measured by objective parameters (laboratory results and measurement) but also by subjective parameters (self­responded outcome, quality of life, and wellnes index). By doing Jamu Scientification for obtaining the scientific evidence of efficacy and safety, it is hoped that we can accelerate the integration of jamu into formal health services.