This book constitutes the refereed proceedings of the 13th Ibero-American Conference on Artificial Intelligence, IBERAMIA 2012, held in Cartagena de Indias, Colombia, in November 2012. The 75 papers presented were carefully reviewed and selected from 170 submissions. The papers are organized in topical sections on knowledge representation and reasoning, information and knowledge processing, knowledge discovery and data mining, machine learning, bio-inspired computing, fuzzy systems, modelling and simulation, ambient intelligence, multi-agent systems, human-computer interaction, natural language processing, computer vision and robotics, planning and scheduling, AI in education, and knowledge engineering and applications.