This book constitutes the proceedings of the 10th German Conference on Multiagent System Technologies held in Trier Germany, in October 2012. The 7 revised full papers presented together with 6 short parers and one invited paper were carefully reviewed and selected from 39 submissions. The paper cover various research topics in intelligent agents and multi-agent-systems. In particular, the conference investigated technologies for truly open distributed systems covering a wide spectrum of approaches from self-organization and autonomous systems to agreement computing.