This book constitutes the refereed proceedings of the 5th International Conference on Social Computing, Behavioral-Cultural Modeling and Prediction, held in College Park, MD, USA, in April 2012. The 43 revised papers presented in this volume were carefully reviewed and selected from 76 submissions. The papers cover a wide range of topics including economics, public health, and terrorist activities, as well as utilize a broad variety of methodologies, e.g., machine learning, cultural modeling and cognitive modeling.