This book constitutes the proceedings of the Sino-foreign-interchange Workshop on Intelligence Science and Intelligent Data Engineering, IScIDE 2011, held in Xi'an, China, in October 2011. The 97 papers presented were carefully peer-reviewed and selected from 389 submissions. The IScIDE papers in this volume are organized in topical sections on machine learning and computational intelligence, pattern recognition, computer vision and image processing, graphics and computer visualization, knowledge discovering, data mining, web mining, multimedia processing and application.