This book contains the refereed proceedings of the 15th International Conference on Business Information Systems, BIS 2012, held in Vilnius, Lithuania, in May 2012. The 26 revised full papers were carefully reviewed and selected from 70 submissions. They are grouped into nine sessions on business process discovery, business process verification, service architectures, collaborative BIS, data management, Web search applications, BIS in finance, decision support, and specific BIS issues.