This volume constitutes the refereed proceedings of the 19th EuroSPI conference, held in Vienna, Austria, in June 2012. The 29 revised papers presented in this volume were carefully reviewed and selected. They are organized in topical sections on SPI and business factors, SPI lifecycle and models, SPI assessment and quality, SPI processes and standards, SPI in SMEs, SPI and implementation, creating environments supporting innovation and improvement, standards and experiences with the implementation of functional safety, business process management, SPI in SMEs - a project management perspective.