ABSTRAKPerkembangan paru yang terjadi sejak masa embrio hingga pascanatal menentukan
efektivitas pertukaran gas, khususnya pada alveolus. Penelitian mengenai struktur
ketebalan dinding alveolus paru dan kaitannya dengan diameter alveolus pascanatal
belum pernah dilaporkan. Penelitian ini bertujuan untuk mengetahui hubungan antara
ketebalan dinding alveolus paru dengan panjang diameter alveolus pada
perkembangan paru neonatus tikus Sprague-Dawley. Jaringan paru tikus Sprague
Dawley usia 2, 4, 10, dan 16 hari yang telah diproses secara histologis dengan
pewarnaan Trichrome Masson, diamati dan difoto di bawah mikroskop, kemudian
diukur ketebalan dinding dan panjang diameter alveolus-nya dengan Optilab Image
Raster. Data disajikan masing-masing dalam bentuk proporsi total ketebalan dinding
alveolus atau panjang diameter alveolus terhadap total panjang horizontal garis di
sepertiga lapang pandang foto. Hasil penelitian menunjukkan adanya peningkatan
ketebalan dinding alveolus paru dan penurunan panjang diameter alveolus dengan
korelasi negatif sedang (uji Pearson; r=-0,523; p=0,009). Disimpulkan bahwa
peningkatan ketebalan dinding alveolus berkorelasi dengan penurunan panjang
diameter alveolus pada paru neonatus tikus Sprague Dawley.
ABSTRACTLung development, which happens during embryonic period until postnatal, will
determine the effectiveness of the gas exchange process. Until recently, study about
the thickness of septum interalveolar and the diameter length of alveolus has not been
reported yet. This study aimed to know the correlation between the thickness of
septum interalveolar and the diameter length of alveolus on postnatal lung
development of Sprague Dawley rat. The Sprague Dawley rats aged 2, 4, 10, and 16
days tissues that were processed histologically with Masson’s Trichrome stain were
observed and photographed using microscope. Subsequently, the septum
interalveolar and diameter were measured by using Optilab Image Raster. The data
were presented each in ratio of total alveolar septum or total alveolar diameter to the
horizontal length of one-third visual field. Our study showed that there is a
significant moderate correlation between the thickness of septum interalveolar and
the diameter length of alveolus on Sprague Dawley rat (Pearson’s test; r=-0.523 ; p=
0.009). As summary, the septum interalveolar increase while the diameter decrease
on lung development of postnatal Sprague Dawley rat.