[Effective Performance Time (EPT) merupakan salah satu indikator performa seorang penerbang terhadap bahaya fisik tekanan udara rendah khususnya hipoksia. Selain karena faktor ketinggian, kecepatan naik, lamanya di ketinggian, suhu udara dan kegiatan fisik di ketinggian terdapat beberapa faktor fisiologis yang mungkin dapat mempengaruhi EPT. Penelitian ini merupakan penelitian analitik dengan desain studi penelitian uji korelasi jenis pra-eksperimental yang melibatkan 106 penerbang sebagai subyek penelitian. Data yang dikumpulkan dalam penelitian ini berasal dari data sekunder hasil Indoktrinasi Latihan Aerofisiologi (ILA) berupa penilaian EPT dan Medical Examination (Medex) seperti Umur, IMT, VO₂max, Hb, GDP, FVC dan FEV1. Hasil penelitian secara statistik menunjukan bahwa ada korelasi positif antara EPT dengan VO2 max (r = 0,400, p = 0,000), Hb (r = 0,271, p = 0,005) dan FVC (r = 0,233, p = 0,016) dan berkorelasi negatif dengan Umur (r = -0,319, p = 0,001), IMT (r = -0,302, p = 0,002), sedangkan GDP (r = -0,186, p = 0,056) dan FEV1 (r = 0,106, p = 0,279) secara statistik tidak memiliki korelasi dengan EPT. Promosi kesehatan menjadi salah satu program untuk menjaga faktor-faktor fisiologis yang dapat mempengaruhi EPT., Effective Performance Time (EPT) is one indicator of the performance of a pilot to hypobaric low pressure hazard particularly hypoxia. In particular hazard because of the altitude, rate of ascent, the length in altitude, temperature and physical activity at the altitude, there are several physiological factors that may affect the EPT. This is analytical research with design study kind of pre-experimental correlation test involving 106 pilot as research subjects. All of the data collected in these study are derived from secondary data in the form of assessment results ILA Effective Performance Time and Medex such as age, BMI, VO₂ max, Hb, GDP, FVC and FEV1. The result of statistical research shows that there is a positive correlation between EPT with VO2 max (r = 0.400, p = 0,000), hemoglobin (r = 0.271, p = 0,005) and FVC (r = 0.233, p = 0,016) and negatively correlated with age (r = -0.319, p = 0,001), BMI (r = -0.302, p = 0,002), while the GDP (r = -0.186, p = 0,056) and FEV1 (r = 0.106, p = 0,279) were not statistically correlated with EPT. Health promotion program to be one factor for maintaining the physiological factors that can affect the EPT.]