[ABSTRAK
Malaria merupakan salah satu penyakit yang sering terjadi di negara tropis dansubtropis. Penyakit malaria banyak terjadi di sebagian besar wilayah Indonesia,seperti Irian Jaya, Nusa Tenggara Barat (NTB) dan Nusa Tenggara Timur (NTT).Berdasarkan data terakhir WHO pada tahun 2013, tercatat sebanyak 198 jutakasus malaria di seluruh dunia, dengan jumlah kematian sebanyak 584.000 jiwa.Pengobatan yang pernah ada untuk jenis malaria Plasmodium falciparum adalahklorokuin, sulfadoksin – pirimetamin, kinin, meflokuin dan artemisinin. Akantetapi, meningkatnya resistensi parasit pada obat antimalaria, melemahkan upayapengendalian malaria. Penambatan molekuler sebagai salah satu metodependekatan in silico telah digunakan pada pencarian senyawa berkhasiat untukmenangani malaria. Dalam satu dekade terakhir, diketahui bahwa senyawaturunan kurkumin memiliki efek sinergis dengan artemisinin terhadapPlasmodium berghei secara in vivo. Pada penelitian ini, dilakukan penambatanmolekuler senyawa turunan kurkumin baru terhadap enzim target antimalaria.Penambatan dilakukan menggunakan piranti lunak AutoDock. Berdasarkan hasilpenambatan, didapatkan senyawa terbaik yang berpotensi sebagai obat antimalariabaru, yang dapat menyerang di sisi aktif tertentu dari Plasmodium falciparum,yaitu : 1,4-dihidrodiazepin-6-morfolinometil kurkumin pada enzim PfDHFR danPirimidin-2-on-5-morfolinometil kurkumin pada enzim PfDHODH.

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ABSTRACT
Malaria is a disease that often occurs in tropical and subtropical countries.Prevalent of malaria in most parts of Indonesia, such as Irian Jaya, West NusaTenggara (NTB) and East Nusa Tenggara (NTT). Based on the WHO's last data in2013, there were 198 million cases of malaria worldwide, with the number ofdeaths by 584,000 inhabitants. Treatment for this type of Plasmodium falciparummalaria is chloroquine, sulfadoxine - pyrimethamine, quinine, mefloquine andartemisinin. However, increasing parasite resistance to the antimalarial drug,making malaria control efforts become effortless. Molecular docking as onemethod in silico approaches have been used in the search for efficaciouscompounds addressing malaria. In the last decade, it is known that the compoundcurcumin analogues have synergistic effect with artemisinin against Plasmodiumberghei in vivo. In this study, we employed docking of new molecular compoundscurcumin derivates as antimalarial target enzymes. Molecular docking isperformed using Autodock. Based on the docking result, best compound isobtained as a potential new antimalarial drug, which can be attacked in certainactive side of Plasmodium falciparum, which is 1,4-dihydrodiazepin-6-morpholinomethyl curcumin on PfDHFR enzyme dan Pyrimidin-2-one-5-morpholinomethyl curcumin on PfDHODH enzyme., Malaria is a disease that often occurs in tropical and subtropical countries.Prevalent of malaria in most parts of Indonesia, such as Irian Jaya, West NusaTenggara (NTB) and East Nusa Tenggara (NTT). Based on the WHO's last data in2013, there were 198 million cases of malaria worldwide, with the number ofdeaths by 584,000 inhabitants. Treatment for this type of Plasmodium falciparummalaria is chloroquine, sulfadoxine - pyrimethamine, quinine, mefloquine andartemisinin. However, increasing parasite resistance to the antimalarial drug,making malaria control efforts become effortless. Molecular docking as onemethod in silico approaches have been used in the search for efficaciouscompounds addressing malaria. In the last decade, it is known that the compoundcurcumin analogues have synergistic effect with artemisinin against Plasmodiumberghei in vivo. In this study, we employed docking of new molecular compoundscurcumin derivates as antimalarial target enzymes. Molecular docking isperformed using Autodock. Based on the docking result, best compound isobtained as a potential new antimalarial drug, which can be attacked in certainactive side of Plasmodium falciparum, which is 1,4-dihydrodiazepin-6-morpholinomethyl curcumin on PfDHFR enzyme dan Pyrimidin-2-one-5-morpholinomethyl curcumin on PfDHODH enzyme.]