UI - Tesis Membership :: Kembali

UI - Tesis Membership :: Kembali

Profil pasien glioma yang menjalani radiasi di RSUPN DR Cipto Mangunkusumo tahun 2009-2014 = The Profile of glioma patients underwent radiation therapy in Cipto Mangunkusumo National Hospital period 2009-2014

Rika Ruhama; Sri Mutya Sekarutami, supervisor; Rahmad Mulyadi, supervisor ([Publisher not identified] , 2015)

 Abstrak

[ABSTRAK
Pendahuluan : Glioma adalah jenis tumor yang paling umum dari neoplasma intraserebral
primer. Tumor ganas primer sistem saraf pusat (SSP) mencapai sekitar 2% dari semua kanker
dan high grade glioma adalah jenis yang paling banyak ditemukan. High grade glioma
menyebabkan tingkat morbiditas dan mortalitas yang tinggi. Saat ini belum ada data yang
menggambarkan profil pasien glioma yang menjalani radioterapi di Indonesia.
Metode penelitian : Penelitian ini merupakan penelitian retrospektif deskriptif analitik
terhadap 121 pasien glioma yang mendapat radiasi di departemen Radioterapi RSUPN Dr.
Cipto mangunkusumo dari Januari 2009 sampai Januari 2014. Data diperoleh dari catatan
medisdan hasil penelusuran melalui telepon terhadap pasien atau keluarganya. Respon tumor
dianalisa terhadap 22 pasien yang mempunyai CT scan atau MRI pre dan post radiasi dengan
menggunakan kriteria RECIST.
Hasil : Sebagian besar pasien adalah laki-laki (53,7%), dengan usia rata-rata 45 tahun.
Histopatologi yang paling banyak ditemukan adalah astrositoma. Prosedur bedah yang paling
banyak ditemukan pada penelitian ini adalah craniotomi removal tumor (70%). Teknik 3D
CRT paling banyak digunakan yaitu pada 77,7% pasien. Nimotuzumab sebagai antibodi
monoklonal digunakan pada 9% pasien. Respon parsial ditemukan 59,1%. Analisis kesintasan
hidup tiga tahun dari seratus sebelas pasien yang memenuhi kriteria didapatkan angka
kesintasan yaitu 46,15%. Analisis kaplan meyer menunjukkan overall treatment time
merupakan faktor prognostik untuk kesintasan hidup (p = 0,016).
Kesimpulan : Teknik operasi terbanyak pada pasien glioma yang menjalani radiasi di
departemen radioterapi RSUPN DR. Cipto Mangunkusumo adalah kraniotomi removal tumor
(70,9%). Teknik 3D CRT adalah teknik radiasi yang paling banyak digunakan. Respon
parsial ditemukan 59,1%. Kesintasan hidup tiga tahun pasien glioma yaitu 46,2% dan overall
treatment time merupakan faktor prognostik yang bermakna untuk kesintasan hidup

ABSTRACT
Introduction : Glioma is the most common type of primary intracerebral neoplasms. High
grade glioma being the most frekuent type found (70,9%) causes a high morbidity and
mortality rate. There is currently no data describing the profile management of patients
undergoing radiotherapy glioma in Indonesia.
Methods : This study Retrospective analytic descriptive study of 121 glioma patients from
januari 2009 until december 2014. The data was obtained from medical records and indivual
contact via telephone. Tumor response was evaluated in 22 patients with pre and post
irradiation imaging (CT or MRI) using 3D volumetric data and assessed via RECIST
criteria.
Results : Most of our patients were male (53,7%), with median age 45 years old.
Astrocytoma was the most histopathological type found. 70.9% of Patients who received
radiotherapy in Cipto Mangunkusumo hospital were post craniotomi tumor removal. 3D
Conformal technique was used in 81.0% of patients. Seventy nine point three had a two gray
dose perfraction. Provision of chemotherapy in patients undergoing radiation still only at
7.4% of patients. Nimotuzumab as a monoclonal antibody used on 9% patient. The median
overall treatment time was 45 days and delay treatment time 38 days. Fifty nine point one
percent of partial respon was found. Local recurrences were found throughout the follow-up
of 6.6%. Analysis kaplan meyer showed that overall treatment time was a prognostic factor
for overal survival rate (p=0,016).
Conclusions : : Almost seventy one percent of glioma patients who received radiotherapy
had craniotomy removal tumor. 3D Conformal techniques is the most widely used. Fifty nine
point one percent of partial respon founded. Three years overall survival was 46,2% and
overall treatment time was found as a factor that significantly affects overall survival
prognosis.;Introduction : Glioma is the most common type of primary intracerebral neoplasms. High
grade glioma being the most frekuent type found (70,9%) causes a high morbidity and
mortality rate. There is currently no data describing the profile management of patients
undergoing radiotherapy glioma in Indonesia.
Methods : This study Retrospective analytic descriptive study of 121 glioma patients from
januari 2009 until december 2014. The data was obtained from medical records and indivual
contact via telephone. Tumor response was evaluated in 22 patients with pre and post
irradiation imaging (CT or MRI) using 3D volumetric data and assessed via RECIST
criteria.
Results : Most of our patients were male (53,7%), with median age 45 years old.
Astrocytoma was the most histopathological type found. 70.9% of Patients who received
radiotherapy in Cipto Mangunkusumo hospital were post craniotomi tumor removal. 3D
Conformal technique was used in 81.0% of patients. Seventy nine point three had a two gray
dose perfraction. Provision of chemotherapy in patients undergoing radiation still only at
7.4% of patients. Nimotuzumab as a monoclonal antibody used on 9% patient. The median
overall treatment time was 45 days and delay treatment time 38 days. Fifty nine point one
percent of partial respon was found. Local recurrences were found throughout the follow-up
of 6.6%. Analysis kaplan meyer showed that overall treatment time was a prognostic factor
for overal survival rate (p=0,016).
Conclusions : : Almost seventy one percent of glioma patients who received radiotherapy
had craniotomy removal tumor. 3D Conformal techniques is the most widely used. Fifty nine
point one percent of partial respon founded. Three years overall survival was 46,2% and
overall treatment time was found as a factor that significantly affects overall survival
prognosis.;Introduction : Glioma is the most common type of primary intracerebral neoplasms. High
grade glioma being the most frekuent type found (70,9%) causes a high morbidity and
mortality rate. There is currently no data describing the profile management of patients
undergoing radiotherapy glioma in Indonesia.
Methods : This study Retrospective analytic descriptive study of 121 glioma patients from
januari 2009 until december 2014. The data was obtained from medical records and indivual
contact via telephone. Tumor response was evaluated in 22 patients with pre and post
irradiation imaging (CT or MRI) using 3D volumetric data and assessed via RECIST
criteria.
Results : Most of our patients were male (53,7%), with median age 45 years old.
Astrocytoma was the most histopathological type found. 70.9% of Patients who received
radiotherapy in Cipto Mangunkusumo hospital were post craniotomi tumor removal. 3D
Conformal technique was used in 81.0% of patients. Seventy nine point three had a two gray
dose perfraction. Provision of chemotherapy in patients undergoing radiation still only at
7.4% of patients. Nimotuzumab as a monoclonal antibody used on 9% patient. The median
overall treatment time was 45 days and delay treatment time 38 days. Fifty nine point one
percent of partial respon was found. Local recurrences were found throughout the follow-up
of 6.6%. Analysis kaplan meyer showed that overall treatment time was a prognostic factor
for overal survival rate (p=0,016).
Conclusions : : Almost seventy one percent of glioma patients who received radiotherapy
had craniotomy removal tumor. 3D Conformal techniques is the most widely used. Fifty nine
point one percent of partial respon founded. Three years overall survival was 46,2% and
overall treatment time was found as a factor that significantly affects overall survival
prognosis., Introduction : Glioma is the most common type of primary intracerebral neoplasms. High
grade glioma being the most frekuent type found (70,9%) causes a high morbidity and
mortality rate. There is currently no data describing the profile management of patients
undergoing radiotherapy glioma in Indonesia.
Methods : This study Retrospective analytic descriptive study of 121 glioma patients from
januari 2009 until december 2014. The data was obtained from medical records and indivual
contact via telephone. Tumor response was evaluated in 22 patients with pre and post
irradiation imaging (CT or MRI) using 3D volumetric data and assessed via RECIST
criteria.
Results : Most of our patients were male (53,7%), with median age 45 years old.
Astrocytoma was the most histopathological type found. 70.9% of Patients who received
radiotherapy in Cipto Mangunkusumo hospital were post craniotomi tumor removal. 3D
Conformal technique was used in 81.0% of patients. Seventy nine point three had a two gray
dose perfraction. Provision of chemotherapy in patients undergoing radiation still only at
7.4% of patients. Nimotuzumab as a monoclonal antibody used on 9% patient. The median
overall treatment time was 45 days and delay treatment time 38 days. Fifty nine point one
percent of partial respon was found. Local recurrences were found throughout the follow-up
of 6.6%. Analysis kaplan meyer showed that overall treatment time was a prognostic factor
for overal survival rate (p=0,016).
Conclusions : : Almost seventy one percent of glioma patients who received radiotherapy
had craniotomy removal tumor. 3D Conformal techniques is the most widely used. Fifty nine
point one percent of partial respon founded. Three years overall survival was 46,2% and
overall treatment time was found as a factor that significantly affects overall survival
prognosis.]

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Jenis Koleksi : UI - Tesis Membership
No. Panggil : T-Pdf
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Entri tambahan-Nama badan :
Program Studi :
Subjek :
Penerbitan : [Place of publication not identified]: [Publisher not identified], 2015
Bahasa : ind
Sumber Pengatalogan : LibUI ind rda
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Deskripsi Fisik : xiv, 57 pages : illustration ; 28 cm + appendix
Naskah Ringkas :
Lembaga Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
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No. Panggil No. Barkod Ketersediaan
T-Pdf 15-17-283186171 TERSEDIA
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